TDG antibody (AA 141-410)
-
- Target See all TDG Antibodies
- TDG (Thymine-DNA Glycosylase (TDG))
-
Binding Specificity
- AA 141-410
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This TDG antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human, Mouse
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human G/T mismatch-specific thymine DNA glycosylase protein (141-410AA)
- Isotype
- IgG
-
anti-Thymine-DNA Glycosylase (TDG) (Internal Region) antibody
TDG Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 81-110), (N-Term) antibodyTDG Reactivity: Human, Mouse WB, FACS Host: Rabbit Polyclonal RB19893 unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 281-310), (C-Term) antibodyTDG Reactivity: Human WB, FACS Host: Rabbit Polyclonal RB19894 unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-410) antibodyTDG Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) antibodyTDG Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) antibodyTDG Reactivity: Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-410) antibodyTDG Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) antibodyTDG Reactivity: Mouse WB Host: Rabbit Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-160) antibodyTDG Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- TDG (Thymine-DNA Glycosylase (TDG))
- Alternative Name
- TDG (TDG Products)
- Synonyms
- 5-MCDG antibody, wu:fb44b11 antibody, zgc:110622 antibody, MGC82456 antibody, MGC89441 antibody, E130317C12Rik antibody, JZA-3 antibody, Jza1 antibody, hTDG antibody, thymine DNA glycosylase antibody, thymine DNA glycosylase, tandem duplicate 1 antibody, putative g/t mismatch-specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, thymine DNA glycosylase S homeolog antibody, thymine-DNA glycosylase antibody, TDG antibody, tdg.1 antibody, Smp_149220 antibody, Tsp_05734 antibody, tdg.S antibody, tdg antibody, Tdg antibody
- Background
-
Background: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Aliases: C JUN leucine zipper interactive protein antibody, C JUN leucine zipper interactive protein antibody, C-JUN leucine zipper interactive protein JZA-3 antibody, E130317C12Rik antibody, EC 3.2.2.29 antibody, G/T mismatch specific thymine DNA glycosylase antibody, G/T mismatch specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, JZA 3 antibody, Jza1 antibody, T:G mismatch thymine glycosylase antibody, Tdg antibody, TDG_HUMAN antibody, Thymine DNA glycosylase antibody, Thymine-DNA glycosylase antibody
- UniProt
- Q13569
- Pathways
- DNA Damage Repair, Chromatin Binding
-
