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MICA antibody

MICA Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7257459
  • Target See all MICA Antibodies
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Reactivity
    • 69
    • 18
    • 14
    • 11
    • 7
    • 4
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 36
    • 33
    Rabbit
    Clonality
    • 36
    • 34
    Polyclonal
    Conjugate
    • 44
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MICA antibody is un-conjugated
    Application
    • 44
    • 37
    • 33
    • 19
    • 17
    • 12
    • 9
    • 8
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human MICA (NP_000238.1).
    Isotype
    IgG
    Top Product
    Discover our top product MICA Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
    Alternative Name
    MICA (MICA Products)
    Synonyms
    MIC-A antibody, PERB11.1 antibody, MHC class I polypeptide-related sequence A antibody, MICA antibody
    Background
    This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
    Molecular Weight

    Observed_MW: 43 kDa

    Calculated_MW: 31 kDa/42 kDa

    Gene ID
    100507436
    UniProt
    Q29983
    Pathways
    Activation of Innate immune Response, Transition Metal Ion Homeostasis
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