Cyclin T2 antibody (Internal Region)
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- Target See all Cyclin T2 (CCNT2) Antibodies
- Cyclin T2 (CCNT2)
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Binding Specificity
- Internal Region
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cyclin T2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- CCNT2 Antibody detects endogenous levels of total CCNT2.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CCNT2 Primary Antibody
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anti-Cyclin T2 (CCNT2) (C-Term) antibody
CCNT2 Reactivity: Human WB, IHC (p), ICC, IF Host: Rabbit Polyclonal unconjugated
anti-Cyclin T2 (CCNT2) (AA 264-370) antibodyCCNT2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1H3 unconjugated
anti-Cyclin T2 (CCNT2) antibodyCCNT2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- Cyclin T2 (CCNT2)
- Alternative Name
- CCNT2 (CCNT2 Products)
- Synonyms
- fb16c03 antibody, wu:fb16c03 antibody, wu:fj68b10 antibody, zgc:55690 antibody, ccnt2 antibody, cycT antibody, wu:fi17h07 antibody, zgc:55357 antibody, MGC81210 antibody, CCNT2 antibody, CYCT2 antibody, 2900041I18Rik antibody, C81304 antibody, CycT2 antibody, CycT2b antibody, cyclin T2 antibody, cyclin T2b antibody, cyclin T2a antibody, cyclin T2 S homeolog antibody, CCNT2 antibody, ccnt2b antibody, ccnt2a antibody, ccnt2.S antibody, ccnt2 antibody, Ccnt2 antibody
- Background
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Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).
Gene: CCNT2
- Molecular Weight
- 81kDa
- Gene ID
- 905
- UniProt
- O60583
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