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CRTC2 antibody (pSer171)

Name: CRTC2 antibody (pSer171)
SKU: ABIN745988
Price: 384.62 USD
Availability: InStock

CRTC2 Reactivity: Human, Mouse WB, ELISA, FACS Host: Rabbit Polyclonal unconjugated

Formalin-fixed and paraffin embedded rat lung labeled with Anti-Phospho-Torc2/Crtc2(Ser171) Polyclonal Antibody (ABIN745988), Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

L1 human rectal carcinoma lysates L2 human gastric carcinoma lysates, probed with Anti Phospho-Torc2/Crtc2(Ser171) Polyclonal Antibody, Unconjugated (ABIN745988) at 1:200 overnight at 4 °C.

SDS

2 images

(4 references)

Catalog No. ABIN745988

Datasheet as PDF

Target See all CRTC2 Antibodies

CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
Binding Specificity
15

8

8

8

7

6

5

5

3

2

1

1

1

1

1

1

1

1

1
pSer171
Reactivity
66

21

7

2

1

1

1

1
Human, Mouse
Host
58

6

4

1
Rabbit
Compatible Secondaries
Clonality
62

7
Polyclonal
Conjugate
29

7

7

6

5

4

1

1

1

1

1

1

1

1

1

1

1
This CRTC2 antibody is un-conjugated
Application
61

42

19

16

6

6

4

3

1

1

1

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Cross-Reactivity

Human, Mouse

Predicted Reactivity

Rat,Dog,Pig

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171

Isotype

IgG

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CRTC2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1E6 unconjugated

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CRTC2 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

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anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 542-553) antibody
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anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 595-693) antibody
CRTC2 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated

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CRTC2 Reactivity: Human WB, IHC (p) Host: Rabbit Monoclonal R08-5F2 unconjugated

anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 180-372) antibody (Biotin)
CRTC2 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin

anti-CREB Regulated Transcription Coactivator 2 (CRTC2) (AA 180-372) antibody (FITC)
CRTC2 Reactivity: Human Host: Rabbit Polyclonal FITC

Application Notes

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date

12 months
Slocum, Skoko, Wakabayashi, Aja, Yamamoto, Kensler, Chartoumpekis: "Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet." in: Archives of biochemistry and biophysics, Vol. 591, pp. 57-65, (2016) (PubMed).

Seok, Fu, Choi, Li, Zhu, Kumar, Sun, Yoon, Kang, Zhong, Ma, Kemper, Kemper: "Transcriptional regulation of autophagy by an FXR-CREB axis." in: Nature, Vol. 516, Issue 7529, pp. 108-11, (2015) (PubMed).

Tian, Zhao, Sun, Zhi, Cheng, Zhou, Hu: "CRTC2 enhances HBV transcription and replication by inducing PGC1? expression." in: Virology journal, Vol. 11, Issue 1, pp. 30, (2014) (PubMed).

Cicerchi, Li, Kratzer, Garcia, Roncal-Jimenez, Tanabe, Hunter, Rivard, Sautin, Gaucher, Johnson, Lanaspa: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).
Target

CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name

TORC2 (CRTC2 Products)

Synonyms

CRTC2 antibody, TORC-2 antibody, TORC2 antibody, 4632407F12Rik antibody, Torc2 antibody, mTORC2 antibody, RGD1308903 antibody, CREB regulated transcription coactivator 2 antibody, CRTC2 antibody, Crtc2 antibody

Background

Synonyms: TORC2, TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2, CRTC2
Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene ID

200186

UniProt

Q53ET0

Pathways

AMPK Signaling, Carbohydrate Homeostasis