Raptor antibody (C-Term)
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- Target See all Raptor (RPTOR) Antibodies
- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Raptor antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Raptor Antibody detects endogenous levels of total Raptor.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human Raptor, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product RPTOR Primary Antibody
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anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 874-1009) antibody
RPTOR Reactivity: Human ELISA, WB Host: Mouse Monoclonal 6G9C4 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 13-128) antibodyRPTOR Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (N-Term) antibodyRPTOR Reactivity: Human, Mouse WB, ICC Host: Rabbit Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (C-Term) antibodyRPTOR Reactivity: Mouse WB, ICC Host: Rabbit Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibodyRPTOR Reactivity: Human ELISA, IHC Host: Rabbit Monoclonal 1B10 unconjugated Recombinant Antibody
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 1005-1329) antibodyRPTOR Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Mouse Monoclonal 1411CT316-2-151-34 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) antibodyRPTOR Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Mouse Monoclonal 14C4 unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 1-379) antibodyRPTOR Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (pSer863) antibodyRPTOR Reactivity: Human DB Host: Rabbit Polyclonal unconjugated
anti-Regulatory Associated Protein of mTOR, Complex 1 (RPTOR) (AA 101-150) antibodyRPTOR Reactivity: Human, Mouse WB, IHC, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
- Alternative Name
- RPTOR (RPTOR Products)
- Synonyms
- KOG1 antibody, Mip1 antibody, 4932417H02Rik antibody, Rap antibody, Raptor antibody, mKIAA1303 antibody, RGD1311784 antibody, raptor antibody, regulatory associated protein of MTOR complex 1 antibody, regulatory associated protein of MTOR, complex 1 antibody, regulatory associated protein of MTOR, complex 1 L homeolog antibody, RPTOR antibody, Rptor antibody, rptor.L antibody, rptor antibody
- Background
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Description: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Gene: RPTOR
- Molecular Weight
- 149kDa
- Gene ID
- 57521
- UniProt
- Q8N122
- Pathways
- PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, Warburg Effect
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