PIK3CB antibody (pSer1070)
(1 reference)-
- Target See all PIK3CB Antibodies
- PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))
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Binding Specificity
- pSer1070
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Reactivity
- Human, Mouse, Rat, Dog, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PIK3CB antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- This phosphorylation site is homologous to that of Ser1064 in Mouse and Ser1070 in Rat.
- Cross-Reactivity
- Dog, Human, Mouse, Rabbit, Rat
- Predicted Reactivity
- Cow,Pig,Horse,Chicken,Guinea Pig
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070
- Isotype
- IgG
- Top Product
- Discover our top product PIK3CB Primary Antibody
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anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 321-507) antibody
PIK3CB Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 807-1070) antibodyPIK3CB Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 524-703) antibodyPIK3CB Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 147-256) antibodyPIK3CB Reactivity: Human WB, ELISA, IHC (p), PLA Host: Mouse Monoclonal 4H2 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 124-154), (N-Term) antibodyPIK3CB Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB11625 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 147-256) antibodyPIK3CB Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 10D5 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (C-Term) antibodyPIK3CB Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 771-1070) antibodyPIK3CB Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) (AA 556-598), (Middle Region) antibodyPIK3CB Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB) antibodyPIK3CB Reactivity: Human WB, ELISA, IP Host: Rabbit Monoclonal 5A9 unconjugated Recombinant Antibody
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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: "Involvement of Akt/GSK3β/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment." in: Neuroscience letters, Vol. 649, pp. 55-61, (2017) (PubMed).
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: "Involvement of Akt/GSK3β/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment." in: Neuroscience letters, Vol. 649, pp. 55-61, (2017) (PubMed).
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- Target
- PIK3CB (Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide (PIK3CB))
- Alternative Name
- PI3 Kinase p110 beta (PIK3CB Products)
- Background
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Synonyms: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PtdIns-3-kinase subunit beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, PtdIns-3-kinase subunit p110-beta, p110beta, PIK3CB, PIK3C1
Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors.
- Gene ID
- 5291
- UniProt
- P42338
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