OSBP antibody (Internal Region)
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- Target See all OSBP Antibodies
- OSBP (Oxysterol Binding Protein (OSBP))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This OSBP antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- OSBP Antibody detects endogenous levels of total OSBP.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human OSBP, corresponding to a region within the internal amino acids.
- Isotype
- IgG
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anti-Oxysterol Binding Protein (OSBP) (AA 324-407) antibody
OSBP Reactivity: Human WB, ELISA Host: Mouse Monoclonal 5A3 unconjugated
anti-Oxysterol Binding Protein (OSBP) (AA 508-807) antibodyOSBP Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Oxysterol Binding Protein (OSBP) (AA 700-749) antibodyOSBP Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Monkey, Pig, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
anti-Oxysterol Binding Protein (OSBP) (AA 628-802) antibodyOSBP Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Oxysterol Binding Protein (OSBP) (C-Term) antibodyVerified OSBP Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-Oxysterol Binding Protein (OSBP) (AA 546-807) antibodyOSBP Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- OSBP (Oxysterol Binding Protein (OSBP))
- Alternative Name
- OSBP (OSBP Products)
- Synonyms
- CG6708 antibody, Dmel\\CG6708 antibody, OSBP-Dm antibody, osbp antibody, OSBP1 antibody, 1110018F06Rik antibody, AW559088 antibody, mKIAA4220 antibody, Oxysterol binding protein antibody, oxysterol binding protein antibody, Osbp antibody, OSBP antibody
- Background
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Description: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
Gene: OSBP
- Molecular Weight
- 89 kDa
- Gene ID
- 5007
- UniProt
- P22059
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