CALCOCO2 antibody (Internal Region)
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- Target See all CALCOCO2 Antibodies
- CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CALCOCO2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- Specificity
- CALCOCO2 Antibody detects endogenous levels of total CALCOCO2.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CALCOCO2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CALCOCO2 Primary Antibody
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anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) (AA 137-446) antibody
CALCOCO2 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) (AA 347-446) antibodyCALCOCO2 Reactivity: Human WB, IF, ELISA Host: Mouse Monoclonal 2A11 unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) antibodyCALCOCO2 Reactivity: Human, Rat, Monkey, Dog WB, IF, FACS Host: Mouse Monoclonal 2D11 unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) (AA 1-446) antibodyCALCOCO2 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) (AA 347-446) antibodyCALCOCO2 Reactivity: Human WB, IF, ELISA Host: Mouse Monoclonal 3C4 unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) (AA 1-446) antibodyCALCOCO2 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) (AA 137-446) antibodyCALCOCO2 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2) antibodyCALCOCO2 Reactivity: Mouse WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))
- Alternative Name
- CALCOCO2 (CALCOCO2 Products)
- Synonyms
- CALCOCO2 antibody, MGC110205 antibody, wu:fj08c01 antibody, zgc:110205 antibody, DKFZp469D2219 antibody, NDP52 antibody, 2410154J16Rik antibody, C77254 antibody, Ndp52 antibody, Ndp52l1 antibody, RGD1559974 antibody, calcium binding and coiled-coil domain 2 antibody, CALCOCO2 antibody, calcoco2 antibody, Calcoco2 antibody
- Background
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Description: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).
Gene: CALCOCO2
- Molecular Weight
- 52 kDa
- Gene ID
- 10241
- UniProt
- Q13137
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