Partner of Y14 and Mago (PYM1) antibody
PYM1
Reactivity: Mouse, Rat
IF, IHC
Host: Rabbit
Polyclonal
unconjugated
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- Target
- Partner of Y14 and Mago (PYM1)
- Reactivity
- Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Immunofluorescence (IF), Immunohistochemistry (IHC)
- Cross-Reactivity
- Rat
- Purification
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse PYM
-
- Application Notes
- IHC/IF (M,R) 1:3000-1:6000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
-
- Target
- Partner of Y14 and Mago (PYM1)
- Alternative Name
- PYM
- Background
- Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated.
- Gene ID
- 78428
- NCBI Accession
- NP_001164340
- UniProt
- Q8CHP5
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