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CACNB4 antibody (Middle Region)

CACNB4 Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2774681
  • Target See all CACNB4 Antibodies
    CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
    Binding Specificity
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 24
    • 15
    • 13
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)
    Host
    • 21
    • 4
    • 1
    Rabbit
    Clonality
    • 24
    • 2
    Polyclonal
    Conjugate
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CACNB4 antibody is un-conjugated
    Application
    • 14
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    FDGRISITRV TADISLAKRS VLNNPSKRAI IERSNTRISS LAEVQSEIER IF
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against CACNB4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human CACNB4
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    Discover our top product CACNB4 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 458 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
    Alternative Name
    CACNB4 (CACNB4 Products)
    Synonyms
    CAB4 antibody, CACNLB4 antibody, EA5 antibody, EIG9 antibody, EJM antibody, EJM4 antibody, EJM6 antibody, 3110038O15Rik antibody, Cchb4 antibody, lethargic antibody, lh antibody, CACNB4 antibody, cacnb4.2 antibody, calcium voltage-gated channel auxiliary subunit beta 4 antibody, calcium channel, voltage-dependent, beta 4 subunit antibody, calcium channel, voltage-dependent, beta 4a subunit antibody, CACNB4 antibody, Cacnb4 antibody, cacnb4.1 antibody, cacnb4 antibody, cacnb4a antibody
    Background
    CACNB4 is a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. CACNB4 plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME).
    Alias Symbols: EA5, EJM, CAB4, EIG9, EJM4, EJM6, CACNLB4
    Protein Interaction Partner: CBX3, FASLG, REM1, MED31, TBL3, CACNA1A, PTN,
    Protein Size: 458
    Molecular Weight
    50 kDa
    Gene ID
    785
    NCBI Accession
    NM_000726, NP_001139270
    UniProt
    A7BJ74
    Pathways
    cAMP Metabolic Process, Skeletal Muscle Fiber Development
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