FIP1L1 antibody
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- Target See all FIP1L1 Antibodies
- FIP1L1 (FIP1 Like 1 (FIP1L1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FIP1L1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human FIP1L1 (NP_001128409.1).
- Isotype
- IgG
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anti-FIP1 Like 1 (FIP1L1) (AA 1-300) antibody
FIP1L1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 1-378) antibodyFIP1L1 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2H4 unconjugated
anti-FIP1 Like 1 (FIP1L1) antibodyFIP1L1 Reactivity: Human, Mouse, Rat WB, IHC, IF, IC Host: Rabbit Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 509-558) antibodyFIP1L1 Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Pig, Guinea Pig, Zebrafish (Danio rerio), Bat, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (C-Term) antibodyFIP1L1 Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio), Rabbit WB, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- FIP1L1 (FIP1 Like 1 (FIP1L1))
- Alternative Name
- FIP1L1 (FIP1L1 Products)
- Background
- This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Molecular Weight
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Observed_MW: 80 kDa
Calculated_MW: 40 kDa/58 kDa/65 kDa/66 kDa
- Gene ID
- 81608
- UniProt
- Q6UN15
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