MSH2 antibody (AA 337-583)
(1 reference)-
- Target See all MSH2 Antibodies
- MSH2 (Mismatch Repair Protein 2 (MSH2))
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Binding Specificity
- AA 337-583
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MSH2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Purpose
- Rabbit IgG polyclonal antibody for DNA mismatch repair protein Msh2(MSH2) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for DNA mismatch repair protein Msh2(MSH2) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: mutS homolog 2
Protein Name: DNA mismatch repair protein Msh2 - Purification
- Immunogen affinity purified.
- Immunogen
- E.coli-derived human MSH2 recombinant protein (Position: Q337-N583). Human MSH2 shares 94% and 93% amino acid (aa) sequence identity with mouse and rat MSH2, respectively.
- Isotype
- IgG
- Top Product
- Discover our top product MSH2 Primary Antibody
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anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibody
MSH2 Reactivity: Human, Mouse WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 2E2C7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 327-427) antibodyMSH2 Reactivity: Human WB, IHC, FACS, StM Host: Mouse Monoclonal MSH2-2622 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibodyMSH2 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibodyMSH2 Reactivity: Human WB, IF, PLA Host: Rabbit Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 4F10D6 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibodyMSH2 Reactivity: Human WB, ELISA, PLA Host: Mouse Monoclonal 4B2 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibodyMSH2 Reactivity: Human IHC, StM Host: Mouse Monoclonal SYP-3551 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 637-665) antibodyMSH2 Reactivity: Human WB, ELISA, IF, FACS Host: Rabbit Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 2-254) antibodyMSH2 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (C-Term) antibodyMSH2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, The detection limit for MSH2 is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth." in: Biomedicine & pharmacotherapy, Vol. 67, Issue 2, pp. 97-102, (2014) (PubMed).
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: "Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth." in: Biomedicine & pharmacotherapy, Vol. 67, Issue 2, pp. 97-102, (2014) (PubMed).
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- Target
- MSH2 (Mismatch Repair Protein 2 (MSH2))
- Alternative Name
- MSH2 (MSH2 Products)
- Synonyms
- COCA1 antibody, FCC1 antibody, HNPCC antibody, HNPCC1 antibody, LCFS2 antibody, AI788990 antibody, wu:fc06b02 antibody, wu:fc13e09 antibody, zgc:55333 antibody, ATMSH2 antibody, MUTS homolog 2 antibody, msh2 antibody, mutS homolog 2 antibody, mutS homolog 2 (E. coli) antibody, MUTS homolog 2 antibody, mutS homolog 2 L homeolog antibody, MutS protein homolog 2 antibody, MSH2 antibody, Msh2 antibody, msh2 antibody, msh2.L antibody
- Background
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DNA mismatch repair protein Msh2, also known as MutS protein homolog 2 or MSH2, is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2 which forms aheterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different forms of DNA repair, including transcription-coupled repair, homologous recombination, and base excision repair. It has been found that MSH2 may also be a coactivator of ESR1-dependent gene expression.
Synonyms: BAT26 antibody|COCA 1 antibody|COCA1 antibody|DNA mismatch repair protein Msh2 antibody|FCC 1 antibody|FCC1 antibody|hMSH2 antibody|HNPCC 1 antibody|HNPCC antibody|HNPCC1 antibody|LCFS2 antibody|MSH 2 antibody|Msh2 antibody|MSH2_HUMAN antibody|MutS homolog 2 antibody|MutS homolog 2 colon cancer nonpolyposis type 1 antibody|MutS protein homolog 2 antibody - Gene ID
- 4436
- UniProt
- P43246
- Pathways
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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