Cullin 3 antibody (AA 411-510)
(1 reference)-
- Target See all Cullin 3 (CUL3) Antibodies
- Cullin 3 (CUL3)
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Binding Specificity
- AA 411-510
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cullin 3 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- This antibody may detect Cullin-4 A/B
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Cullin 3
- Isotype
- IgG
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anti-Cullin 3 (CUL3) antibody
CUL3 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Cullin 3 (CUL3) antibodyCUL3 Reactivity: Human, Mouse, Rat IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Cullin 3 (CUL3) (AA 569-768) antibodyCUL3 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Cullin 3 (CUL3) antibodyCUL3 Reactivity: Human IHC, ELISA Host: Rabbit Monoclonal 7B6 unconjugated Recombinant Antibody
anti-Cullin 3 (CUL3) (AA 301-400) antibodyCUL3 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1A3 unconjugated
anti-Cullin 3 (CUL3) (AA 618-667) antibodyCUL3 Reactivity: Human, Zebrafish (Danio rerio), Cow, Chicken, Dog, Guinea Pig, Horse, Rabbit, Monkey, Bat, Pig WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Cullin 3 (CUL3) (N-Term) antibodyCUL3 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Cullin 3 (CUL3) (N-Term) antibodyCUL3 Reactivity: Human, Mouse IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Cullin 3 (CUL3) (Internal Region) antibodyVerified CUL3 Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-Cullin 3 (CUL3) antibodyCUL3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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: "Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation." in: Chemical research in toxicology, Vol. 28, Issue 4, pp. 765-74, (2015) (PubMed).
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: "Tetrachlorobenzoquinone activates nrf2 signaling by keap1 cross-linking and ubiquitin translocation but not keap1-cullin3 complex dissociation." in: Chemical research in toxicology, Vol. 28, Issue 4, pp. 765-74, (2015) (PubMed).
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- Target
- Cullin 3 (CUL3)
- Alternative Name
- Cullin 3 (CUL3 Products)
- Synonyms
- CUL-3 antibody, Cullin-3 antibody, CUL-3-A antibody, Cullin-3-A antibody, cul3 antibody, cul3a antibody, CUL-3-B antibody, Cullin-3-B antibody, cul3b antibody, wu:fc37e01 antibody, CUL3 antibody, ATCUL3 antibody, ATCUL3A antibody, CUL3A antibody, T24P13.25 antibody, cullin 3 antibody, cullin 3A antibody, PHA2E antibody, AI467304 antibody, AW146203 antibody, mKIAA0617 antibody, cullin 3 antibody, cullin 3 L homeolog antibody, cullin 3 S homeolog antibody, cullin-3 antibody, Cullin-3 (CUL-3) antibody, cullin 3a antibody, CULlin antibody, CUL3 antibody, cul3 antibody, cul3.L antibody, cul3.S antibody, PTRG_11586 antibody, Smp_117580 antibody, cul3a antibody, Cul3 antibody, cul-3 antibody
- Background
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Synonyms: CUL-3, PHA2E, Cullin-3, CUL3, KIAA0617
Background: Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, these complexes have lower ubiquitin ligase activity. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis. BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, by mediating ubiquitination of WNK4. The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, PubMed:21840486, PubMed:21670212, PubMed:24768539).
- Gene ID
- 8452
- UniProt
- Q13618
- Pathways
- M Phase
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