PPP1R9B antibody (C-Term)
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- Target See all PPP1R9B Antibodies
- PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))
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Binding Specificity
- C-Term
- Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PPP1R9B antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
- Specificity
- NEB2 Antibody detects endogenous levels of total NEB2.
- Predicted Reactivity
- Pig,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NEB2, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
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anti-Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) (AA 708-817) antibody
PPP1R9B Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) antibodyPPP1R9B Reactivity: Human, Mouse IF Host: Rabbit Polyclonal unconjugated
anti-Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B) (AA 358-460) antibodyPPP1R9B Reactivity: Rat, Mouse WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))
- Alternative Name
- PPP1R9B (PPP1R9B Products)
- Synonyms
- Neb2 antibody, PPP1R6 antibody, PPP1R9 antibody, SPINO antibody, Spn antibody, SPL antibody, protein phosphatase 1, regulatory subunit 9B antibody, protein phosphatase 1 regulatory subunit 9B antibody, Ppp1r9b antibody, PPP1R9B antibody
- Background
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Description: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.
Gene: PPP1R9B
- Molecular Weight
- 89 kDa
- Gene ID
- 84687
- UniProt
- Q96SB3
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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