SUCLA2 antibody
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- Target See all SUCLA2 Antibodies
- SUCLA2 (Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SUCLA2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse
- Characteristics
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Rabbit Polyclonal antibody to SUCLA2 (succinate-CoA ligase, ADP-forming, beta subunit)
SUCLA2 antibody [N2C3] - Purification
- Purified by antigen-affinity chromatography.
- Grade
- KO Validated
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human SUCLA2. The exact sequence is proprietary.
- Isotype
- IgG
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anti-Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) (AA 1-180) antibody
SUCLA2 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) (Internal Region) antibodySUCLA2 Reactivity: Human, Mouse, Rat WB, IHC, ICC, IF Host: Rabbit Polyclonal unconjugated
anti-Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) (C-Term) antibodySUCLA2 Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Dog, Rabbit, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
anti-Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) (N-Term) antibodySUCLA2 Reactivity: Human, Mouse, Rat, Pig, Cow, Horse, Dog, Rabbit, Guinea Pig, Saccharomyces cerevisiae, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: Mouse brain , HepG2 , Molt-4 , HeLa
Validation: KO/KD
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- SUCLA2 (Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2))
- Alternative Name
- succinate-CoA ligase ADP-forming beta subunit (SUCLA2 Products)
- Synonyms
- 4930547K18Rik antibody, A-BETA antibody, MTDPS5 antibody, SCS-betaA antibody, SCS antibody, succinate-Coenzyme A ligase, ADP-forming, beta subunit antibody, succinate-CoA ligase ADP-forming beta subunit antibody, Sucla2 antibody, SUCLA2 antibody
- Background
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Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.
Cellular Localization: Mitochondrion - Molecular Weight
- 50 kDa
- Gene ID
- 8803
- UniProt
- Q9P2R7
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