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BTRC antibody (AA 24-151)

BTRC Reactivity: Human WB, ELISA, IHC, ICC, FACS, Neut Host: Mouse Monoclonal 4C5D8 unconjugated
Catalog No. ABIN5611131
  • Target See all BTRC Antibodies
    BTRC (beta-Transducin Repeat Containing (BTRC))
    Binding Specificity
    • 10
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 24-151
    Reactivity
    • 44
    • 16
    • 12
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 44
    • 4
    Mouse
    Clonality
    • 44
    • 4
    Monoclonal
    Conjugate
    • 21
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BTRC antibody is un-conjugated
    Application
    • 28
    • 23
    • 20
    • 16
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. coli.
    Clone
    4C5D8
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    BTRC (beta-Transducin Repeat Containing (BTRC))
    Alternative Name
    BTRC (BTRC Products)
    Synonyms
    BTRC antibody, Beta-TrCP antibody, betaTrCP antibody, btrcp antibody, btrcp1 antibody, fbw1a antibody, fbxw1 antibody, fbxw1a antibody, fwd1 antibody, btrc antibody, beta-TrCP antibody, BETA-TRCP antibody, FBW1A antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, bTrCP antibody, bTrCP1 antibody, beta-TrCP1 antibody, btrc-a antibody, Beta-Trcp1 antibody, Fbw1a antibody, HOS antibody, Slimb antibody, b-TrCP antibody, mKIAA4123 antibody, beta-transducin repeat containing E3 ubiquitin protein ligase antibody, beta-transducin repeat containing antibody, beta-TrCP antibody, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog antibody, beta-transducin repeat containing protein antibody, BTRC antibody, btrc antibody, LOC100634006 antibody, Btrc antibody, btrc.S antibody
    Background

    Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

    Aliases: FWD1, FBW1A, FBXW1, bTrCP, FBXW1A, bTrCP1, betaTrCP, BETA-TRCP

    Molecular Weight
    68.9 kDa
    Gene ID
    8945
    HGNC
    8945
    Pathways
    Cell Division Cycle, Hedgehog Signaling
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