MTMR4 antibody (C-Term)
(3 references)-
- Target See all MTMR4 Antibodies
- MTMR4 (Myotubularin Related Protein 4 (MTMR4))
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Binding Specificity
- AA 1155-1187, C-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MTMR4 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.
- Clone
- RB0716
- Isotype
- Ig Fraction
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anti-Myotubularin Related Protein 4 (MTMR4) (AA 920-1195) antibody
MTMR4 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Myotubularin Related Protein 4 (MTMR4) (AA 570-820) antibodyMTMR4 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Myotubularin Related Protein 4 (MTMR4) (C-Term) antibodyMTMR4 Reactivity: Human, Mouse WB, ELISA, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Myotubularin Related Protein 4 (MTMR4) (AA 695-723) antibodyMTMR4 Reactivity: Human WB Host: Rabbit Polyclonal RB36820 unconjugated
anti-Myotubularin Related Protein 4 (MTMR4) antibodyMTMR4 Reactivity: Human, Mouse IF Host: Rabbit Polyclonal unconjugated
anti-Myotubularin Related Protein 4 (MTMR4) (AA 1-1195) antibodyMTMR4 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
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- Application Notes
- WB: 1:1000. IHC-P: 1:10~50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Expiry Date
- 6 months
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: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).
: "MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8454-62, (2010) (PubMed).
: "The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4." in: The Biochemical journal, Vol. 419, Issue 1, pp. 57-63, (2009) (PubMed).
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: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).
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- Target
- MTMR4 (Myotubularin Related Protein 4 (MTMR4))
- Alternative Name
- MTMR4 (MTMR4 Products)
- Background
- MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47 % sequence identity with MTMR3, spiking to over 70 % identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.
- Molecular Weight
- 133353
- Gene ID
- 9110
- NCBI Accession
- NP_004678
- UniProt
- Q9NYA4
- Pathways
- Inositol Metabolic Process
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