LATS1 antibody (AA 1-280)
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- Target See all LATS1 Antibodies
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
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Binding Specificity
- AA 1-280
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LATS1 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
- Isotype
- IgG
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anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Internal Region) antibody
LATS1 Reactivity: Human, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30), (N-Term) antibodyLATS1 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal RB3029 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 521-620) antibodyLATS1 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 3A7 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibodyLATS1 Reactivity: Human, Mouse WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30) antibodyLATS1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1041), (pThr1079) antibodyLATS1 Reactivity: Human, Mouse IHC (p) Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-1130) antibodyLATS1 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 971-1020) antibodyLATS1 Reactivity: Human, Mouse, Rat, Dog, Horse, Monkey, Cow, Rabbit, Zebrafish (Danio rerio), Bat, Hamster WB Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Middle Region) antibodyLATS1 Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Zebrafish (Danio rerio), Saccharomyces cerevisiae, Sheep WB Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (N-Term) antibodyLATS1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: IHC:1:100-1:1200, IF:1:50-1:500, IP:1:200-1:2000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
- Alternative Name
- LATS1 (LATS1 Products)
- Synonyms
- WARTS antibody, wts antibody, AW208599 antibody, Lats antibody, si:dkey-181i3.5 antibody, wu:fc19a11 antibody, zgc:123219 antibody, lats1 antibody, RGD1564085 antibody, warts antibody, large tumor suppressor kinase 1 antibody, large tumor suppressor antibody, large tumor suppressor kinase 1 S homeolog antibody, LATS1 antibody, Lats1 antibody, lats1 antibody, lats1.S antibody
- Background
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Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Aliases: h-warts antibody, Large tumor suppressor homolog 1 antibody, LATS large tumor suppressor homolog 1 antibody, LATS1 antibody, LATS1_HUMAN antibody, Serine threonine protein kinase LATS1 antibody, Serine/threonine-protein kinase LATS1 antibody, WARTS antibody, WARTS protein kinase antibody, wts antibody
- UniProt
- O95835
- Pathways
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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