MSK1 antibody (AA 224-367)
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- Target See all MSK1 (RPS6KA5) Antibodies
- MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
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Binding Specificity
- AA 224-367
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MSK1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Ribosomal protein S6 kinase alpha-5 protein (224-367AA)
- Isotype
- IgG
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anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 271-370) antibody
RPS6KA5 Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 2B11 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pSer376) antibodyRPS6KA5 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 540-665) antibodyRPS6KA5 Reactivity: Human, Mouse, Rat WB, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (AA 1-802) antibodyRPS6KA5 Reactivity: Human WB, PLA Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) antibodyRPS6KA5 Reactivity: Human ELISA, IHC, IHC (p) Host: Mouse Monoclonal 1G7 unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (Ser212) antibodyRPS6KA5 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (Internal Region) antibodyRPS6KA5 Reactivity: Human, Mouse WB, IF, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (C-Term) antibodyRPS6KA5 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pSer360) antibodyRPS6KA5 Reactivity: Mouse, Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pSer212) antibodyRPS6KA5 Reactivity: Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))
- Alternative Name
- RPS6KA5 (RPS6KA5 Products)
- Synonyms
- MSK1 antibody, MSPK1 antibody, RLPK antibody, 3110005L17Rik antibody, 6330404E13Rik antibody, AI854034 antibody, Msk1 antibody, ribosomal protein S6 kinase A5 antibody, ribosomal protein S6 kinase, polypeptide 5 antibody, RPS6KA5 antibody, Rps6ka5 antibody
- Background
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Background: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at \\\'Ser-276\\\' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the \\\'Ser-727\\\' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at \\\'Ser-191\\\' and \\\'Ser-216\\\', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of \\\'Ser-1\\\' of histone H2A. Phosphorylates \\\'Ser-10\\\' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate \\\'Ser-28\\\' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.
Aliases: 90 kDa ribosomal protein S6 kinase 5 antibody, EC 2.7.11.1 antibody, KS6A5_HUMAN antibody, MGC1911 antibody, Mitogen and stress activated protein kinase 1 antibody, MSPK1 antibody, Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody, Nuclear mitogen- and stress-activated protein kinase 1 antibody, Ribosomal protein S6 kinase 90kD polypeptide 5 antibody, Ribosomal protein S6 kinase 90 kDa antibody, Ribosomal protein S6 kinase 90 kDa polypeptide 5 antibody, Ribosomal Protein S6 Kinase Alpha 5 antibody, Ribosomal protein S6 kinase alpha-5 antibody, RLPK antibody, RPS6KA5 antibody, RSK Like Protein Kinase antibody, RSK-like protein kinase antibody, RSKL antibody, S6K alpha 5 antibody, S6K-alpha-5 antibody
- UniProt
- O75582
- Pathways
- MAPK Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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