POM121 antibody (N-Term)
(5 references)-
- Target See all POM121 Antibodies
- POM121 (POM121 Membrane Glycoprotein (POM121))
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Binding Specificity
- N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POM121 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Cross-Reactivity
- Human, Mouse
- Characteristics
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Rabbit Polyclonal antibody to POM121 (POM121 membrane glycoprotein (rat))
POM121 antibody [N2N3] - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the N-terminus region of human POM121. The exact sequence is proprietary.
- Isotype
- IgG
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anti-POM121 Membrane Glycoprotein (POM121) antibody
POM121 Reactivity: Human, Rat, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-POM121 Membrane Glycoprotein (POM121) antibodyPOM121 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-POM121 Membrane Glycoprotein (POM121) (AA 1197-1246) antibodyPOM121 Reactivity: Human, Rat, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: A549
Validation: Orthogonal
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.16 mg/mL
- Buffer
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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: "POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma." in: Journal of Cancer, Vol. 10, Issue 19, pp. 4473-4480, (2019) (PubMed).
: "Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. ..." in: Cell, Vol. 174, Issue 5, pp. 1200-1215.e20, (2019) (PubMed).
: "Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons." in: Acta neuropathologica, Vol. 132, Issue 1, pp. 77-91, (2017) (PubMed).
: "Analysis of the initiation of nuclear pore assembly by ectopically targeting nucleoporins to chromatin." in: Nucleus (Austin, Tex.), Vol. 6, Issue 1, pp. 40-54, (2015) (PubMed).
: "The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function." in: Molecular biology of the cell, Vol. 25, Issue 1, pp. 160-8, (2014) (PubMed).
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: "POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma." in: Journal of Cancer, Vol. 10, Issue 19, pp. 4473-4480, (2019) (PubMed).
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- Target
- POM121 (POM121 Membrane Glycoprotein (POM121))
- Alternative Name
- POM121 transmembrane nucleoporin (POM121 Products)
- Synonyms
- P145 antibody, POM121A antibody, 2610027A18Rik antibody, C80273 antibody, mKIAA0618 antibody, POM121C antibody, POM121 antibody, wu:fa16c07 antibody, wu:fl35g12 antibody, POM121 transmembrane nucleoporin antibody, nuclear pore membrane protein 121 antibody, POM121 transmembrane nucleoporin C-like antibody, POM121 transmembrane nucleoporin C antibody, nuclear envelope pore membrane protein POM 121C antibody, POM121 membrane glycoprotein b antibody, POM121 antibody, Pom121 antibody, POM121CL antibody, POM121C antibody, pom121 antibody, LOC100604279 antibody, pom121-b antibody
- Background
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The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
Cellular Localization: Nucleus , nuclear pore complex , Nucleus membrane, Single-pass membrane protein , Endoplasmic reticulum membrane, Single-pass membrane protein (By similarity) - Molecular Weight
- 128 kDa
- Gene ID
- 9883
- UniProt
- Q96HA1
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