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CDC42 antibody (AA 25-191)
CDC42
Reactivity: Human
WB, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CDC42 Antibody
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Target
See all CDC42 Antibodies
CDC42
(Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))
Binding Specificity
All epitopes for CDC42 antibodies
AA 25-191
Reactivity
All reactivities for CDC42 antibodies
Human
Host
All hosts for CDC42 antibodies
Rabbit
Clonality
All clonalities for CDC42 antibodies
Polyclonal
Conjugate
All conjugates for CDC42 antibodies
This CDC42 antibody is un-conjugated
Application
All applications for CDC42 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Sequence
TNKFPSEYVP TVFDNYAVTV MIGGEPYTLG LFDTAGQEDY DRLRPLSYPQ TDVFLVCFSV VSPSSFENVK EKWVPEITHH CPKTPFLLVG TQIDLRDDPS TIEKLAKNKQ KPITPETAEK LARDLKAVKY VECSALTQKG LKNVFDEAIL AALEPPEPKK SRRCVLL
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Purification
Affinity purification
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-191 of human CDC42 (NP_001782.1).
Isotype
IgG
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze / thaw cycles
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
References for anti-CDC42 antibody (ABIN3021671)
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Liu, Feng, Chen, Luo, Yan, Chen, Lin, Ding, Wen : "Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition. " in: Molecular neurobiology , Vol. 55 , Issue 1 , pp. 763-775 , (2018 ) (PubMed ).
Fang, Li, Han, Zhao, Gao, Yan, Luo : "Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats. " in: Biochemical and biophysical research communications , Vol. 490 , Issue 3 , pp. 719-725 , (2017 ) (PubMed ).
Target Details for CDC42
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Target
CDC42
(Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))
Alternative Name
CDC42 (CDC42 Products )
Synonyms
CDC42Hs antibody, G25K antibody, AI747189 antibody, AU018915 antibody, cdc42a antibody, wu:fb07d08 antibody, wu:fj62g06 antibody, zgc:63918 antibody, Xcdc42 antibody, cdc42hs antibody, g25k antibody, CDC42 antibody, CG12530 antibody, Cdc42Dm antibody, D-CDC42 antibody, D-Cdc42 antibody, D-cdc42 antibody, DCDC42 antibody, DCdc42 antibody, Dcdc42 antibody, Dm Cdc42 antibody, DmCDC42 antibody, Dmcdc42 antibody, Dmel\\CG12530 antibody, cdc42 antibody, cell division cycle 42 antibody, Cell division control protein 42 homolog antibody, cell division control protein 42 homolog antibody, cell division cycle 42 L homeolog antibody, CG12530 gene product from transcript CG12530-RC antibody, Rho family GTPase antibody, CDC42 antibody, Cdc42 antibody, cdc42 antibody, LOC100636735 antibody, LOC100637699 antibody, LOC100638834 antibody, cdc42.L antibody
Background
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.,CDC42,CDC42Hs,G25K,TKS,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cell Adhesion,Cytoskeleton,Microtubules,Actins,TGF-b-Smad Signaling Pathway,Immunology & Inflammation,Cytokines,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,CDC42
Molecular Weight
21 kDa
Gene ID
998
UniProt
P60953
Pathways
MAPK Signaling , Microtubule Dynamics , RTK Signaling , WNT Signaling , TCR Signaling , EGFR Signaling Pathway , Regulation of Actin Filament Polymerization , Regulation of Muscle Cell Differentiation , Cell-Cell Junction Organization , Maintenance of Protein Location , Skeletal Muscle Fiber Development , Signaling Events mediated by VEGFR1 and VEGFR2 , EGFR Downregulation , VEGF Signaling
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