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Human Polyclonal DERL1 Primary Antibody for IHC - ABIN965990
Lilley, Ploegh: A membrane protein required for dislocation of misfolded proteins from the ER. in Nature 2004
Show all 3 references for ABIN965990
Chinese Hamster Polyclonal DERL1 Primary Antibody for ICC, IF - ABIN151899
Huttunen, Guénette, Peach, Greco, Xia, Kim, Barren, Tanzi, Kovacs: HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. in The Journal of biological chemistry 2007
Show all 2 references for ABIN151899
Human Polyclonal DERL1 Primary Antibody for EIA, FACS - ABIN453618
Oda, Okada, Yoshida, Kaufman, Nagata, Mori: Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. in The Journal of cell biology 2006
Show all 2 references for ABIN453618
Cav-1 (show CAV1 Antibodies) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 (show COX2 Antibodies) and may facilitate Derlin-1- and p97 (show EIF4G2 Antibodies) complex-mediated COX-2 (show COX2 Antibodies) ubiquitination, retrotranslocation, and degradation.
Derlin-1 deficiency is embryonic lethal, Derlin-3 (show DERL3 Antibodies) deficiency appears normal, and Herp (show HERPUD1 Antibodies) deficiency is intolerant to glucose load and ischemia in mice
Derlin-1 regulates the turnover of superoxide dismutase 1 (show SOD1 Antibodies) by promoting the proteasomal and autophagosomal degradation of SOD1 (show SOD1 Antibodies) protein, but not by decreasing mutant SOD1 (show SOD1 Antibodies) mRNA levels.
Perturbation of binding between SOD1 (show SOD1 Antibodies)(mut (show MUT Antibodies)) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1 (show SOD1 Antibodies)(mut (show MUT Antibodies))-induced ER stress, ASK1 (show MAP3K5 Antibodies) activation, and motor neuron death.
insights into the interactions between other SHP (show LAMC1 Antibodies)-containing proteins and p97N
data suggest that miR (show MLXIP Antibodies)-181d is a tumor suppressor in ESCC inversely regulating its downstream target gene of DERL1.
Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells.
TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1.
Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR (show EGFR Antibodies)-ERK (show EPHB2 Antibodies)-mediated up-regulation of MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies).
Upregulation of derlin-1 may be associated with endoplasmic reticulum stress in neuronal cells in Alzheimer's disease.
These results indicate that ApoB (show APOB Antibodies) after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 (show FAF2 Antibodies) are engaged in the predislocation and postdislocation steps, respectively.
Derlin-1 expression levels may affect glucose-stimulated insulin (show INS Antibodies) secretion by altering surface expression of K(ATP) channels.
Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP (show ABCG2 Antibodies) expression and provide a novel posttranslational regulatory mechanism of BCRP (show ABCG2 Antibodies) by Derlin-1.
A role for DERL1 in tissue remodeling events and maintenance of function in reproductive tissues.
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
, Dm Derlin-1
, Der1-like domain family, member 1
, Der1-like protein 1
, degradation in endoplasmic reticulum protein 1
, der1-like protein 1