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The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC (show SCNN1A ELISA Kits) in mammalian cells.
Cav-1 (show CAV1 ELISA Kits) may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 (show COX2 ELISA Kits) and may facilitate Derlin-1- and p97 (show EIF4G2 ELISA Kits) complex-mediated COX-2 (show COX2 ELISA Kits) ubiquitination, retrotranslocation, and degradation.
Derlin-1 deficiency is embryonic lethal, Derlin-3 (show DERL3 ELISA Kits) deficiency appears normal, and Herp (show HERPUD1 ELISA Kits) deficiency is intolerant to glucose load and ischemia in mice
Derlin-1 regulates the turnover of superoxide dismutase 1 (show SOD1 ELISA Kits) by promoting the proteasomal and autophagosomal degradation of SOD1 (show SOD1 ELISA Kits) protein, but not by decreasing mutant SOD1 (show SOD1 ELISA Kits) mRNA levels.
Perturbation of binding between SOD1 (show SOD1 ELISA Kits)(mut (show MUT ELISA Kits)) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1 (show SOD1 ELISA Kits)(mut (show MUT ELISA Kits))-induced ER stress, ASK1 (show MAP3K5 ELISA Kits) activation, and motor neuron death.
Derlin-1 is overexpressed in bladder cancer and promotes malignant phenotype through ERK (show EPHB2 ELISA Kits)/MMP-2 (show MMP2 ELISA Kits)/9 and PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.
Derlin-1 was overexpressed in bladder cancer and was associated with the malignancy of bladder cancer.
insights into the interactions between other SHP (show LAMC1 ELISA Kits)-containing proteins and p97N
data suggest that miR (show MLXIP ELISA Kits)-181d is a tumor suppressor in ESCC inversely regulating its downstream target gene of DERL1.
Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells.
TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1.
Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR (show EGFR ELISA Kits)-ERK (show EPHB2 ELISA Kits)-mediated up-regulation of MMP-2 (show MMP2 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits).
Upregulation of derlin-1 may be associated with endoplasmic reticulum stress in neuronal cells in Alzheimer's disease.
A role for DERL1 in tissue remodeling events and maintenance of function in reproductive tissues.
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
, Dm Derlin-1
, Der1-like domain family, member 1
, Der1-like protein 1
, degradation in endoplasmic reticulum protein 1
, der1-like protein 1