Browse our anti-EIF2AK2 (EIF2AK2) Antibodies

Full name:
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 Antibodies (EIF2AK2)
On www.antibodies-online.com are 270 Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) Antibodies from 28 different suppliers available. Additionally we are shipping EIF2AK2 Kits (17) and EIF2AK2 Proteins (6) and many more products for this protein. A total of 312 EIF2AK2 products are currently listed.
Synonyms:
2310047A08Rik, 4732414G15Rik, AI467567, AI747578, DKFZp469K1934, EIF2AK1, EIF2AK2, Pkr, Prkr, Tik
list all antibodies Gene Name GeneID UniProt
EIF2AK2 5610 P19525
EIF2AK2 19106 Q03963
EIF2AK2 54287 Q63184

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Most Popular Reactivities for anti-EIF2AK2 (EIF2AK2) Antibodies

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anti-Rat (Rattus) EIF2AK2 Antibodies:

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Top referenced anti-EIF2AK2 Antibodies

  1. Human Polyclonal EIF2AK2 Primary Antibody for EIA, IHC (p) - ABIN360664 : Peel, Bredesen: Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. in Neurobiology of disease 2003 (PubMed)
    Show all 5 references for 360664

  2. Human Polyclonal EIF2AK2 Primary Antibody for EIA, IHC (p) - ABIN360663 : Pang, Christianson, Keeble, Koretsky, Bagby: The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for 360663

  3. Human Monoclonal EIF2AK2 Primary Antibody for IF, IP - ABIN968165 : Barber, Tomita, Hovanessian, Meurs, Katze: Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli. in Biochemistry 1991 (PubMed)
    Show all 4 references for 968165

  4. Human Polyclonal EIF2AK2 Primary Antibody for IF, IHC (p) - ABIN197544 : Pataer, Vorburger, Barber, Chada, Mhashilkar, Zou-Yang, Stewart, Balachandran, Roth, Hunt, Swisher: Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). in Cancer research 2002 (PubMed)
    Show all 3 references for 197544

  5. Human Polyclonal EIF2AK2 Primary Antibody for IF, IHC (p) - ABIN197048 : Ryman, Meier, Nangle, Ragsdale, Korneeva, Rhoads, MacDonald, Klimstra: Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells. in Journal of virology 2005 (PubMed)
    Show all 3 references for 197048

  6. Human Polyclonal EIF2AK2 Primary Antibody for ELISA, WB - ABIN1533108 : Meurs, Chong, Galabru, Thomas, Kerr, Williams, Hovanessian: Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. in Cell 1990 (PubMed)
    Show all 3 references for 1533108

  7. Human Polyclonal EIF2AK2 Primary Antibody for IHC, ELISA - ABIN1532075 : Thomis, Doohan, Samuel: Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells. in Virology 1992 (PubMed)
    Show all 3 references for 1532075

  8. Human Polyclonal EIF2AK2 Primary Antibody for IHC, WB - ABIN2792224 : Alisi, Mele, Spaziani, Tavolaro, Palescandolo, Balsano: Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells. in Journal of cellular physiology 2005 (PubMed)

More Antibodies against EIF2AK2 Interaction Partners

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (show PKLR Antibodies) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha (show EIF2S1 Antibodies).

  2. Protein kinase (show CDK7 Antibodies) R (PKR (show PKLR Antibodies)) was required for induction of stress granules (SGs (show FBN1 Antibodies)) by mumps virus (MuV) infection and regulated type III IFN (IFN-lambda1) mRNA stability.

  3. data establish a model in which the Influenza A virus NS1 (show PTPN11 Antibodies) N-terminal domain engages in a binding interaction to inhibit activation of PKR (show PKLR Antibodies) and ensure efficient viral propagation and virulence

  4. It was established in this report that interactions between PACT (show RBBP6 Antibodies), ADAR1 (show ADAR Antibodies) and HIV-1-encoded Tat (show TAT Antibodies) protein diminish the activation of PKR (show PKLR Antibodies) in response to HIV-1 infection.

  5. In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (show GBP1 Antibodies), TLR3 (show TLR3 Antibodies), OAS1 (show OAS1 Antibodies), EIF2AK2, HLA-E (show HLAE Antibodies), IFI6 (show IFI6 Antibodies), and STAT1 (show STAT1 Antibodies), showed higher expression in the islet core compared with the peri (show PLIN1 Antibodies)-islet area containing the surrounding immune cells

  6. NF90 (show MMP4 Antibodies) exerts its antiviral activity by antagonizing the inhibitory role of NS1 (show PTPN11 Antibodies) on PKR (show PKLR Antibodies) phosphorylation

  7. Crucially, Chlamydia trachomatis infection resulted in robust IRE1alpha (show ERN1 Antibodies) RNAse activity that was dependent on TLR4 (show TLR4 Antibodies) signalling and inhibition of IRE1alpha (show ERN1 Antibodies) RNAse activity prevented PKR (show PKLR Antibodies) activation.

  8. the expression of a Tat (show TAT Antibodies) construct containing mutations in the basic region (49-57aa), which is responsible for the interaction with PKR (show PKLR Antibodies), favored neither parasite growth nor IL-10 (show IL10 Antibodies) expression in infected macrophages.

  9. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL Antibodies) and HDAC8 (show HDAC8 Antibodies) mutations and PKR (show PKLR Antibodies) activation.

  10. The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 Antibodies), which is mediated by continual activation of PKR (show PKLR Antibodies) and degradation of PP1 (show PPA1 Antibodies).

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. PKR activation is an essential part of the molecular switch from adaptation to inflammation in response to hyperosmotic stress.

  2. We therefore concluded that in osteoblasts, P. gingivalis activated PKR, which in turn increased NLRP3 (show NLRP3 Antibodies) expression by activating NF-kappaB (show NFKB1 Antibodies). Our results suggest that PKR modulates inflammation by regulating the expression of the NLRP3 (show NLRP3 Antibodies) inflammasome through the NF-kappaB (show NFKB1 Antibodies) pathway in periodontal diseases.

  3. identify iNOS (show NOS2 Antibodies)/NO as an integral component of IFN-beta (show IFNB1 Antibodies) production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3 (show TLR3 Antibodies)/Trif (show RNF138 Antibodies) and PKR

  4. The data predicts that PKR diminishes inflammasome activity by controlling protein translation to repress the induction of factors that are critical for the activity of the cryopyrin (show NLRP3 Antibodies) inflammasome.

  5. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL Antibodies) and HDAC8 (show HDAC8 Antibodies) mutations and PKR activation.

  6. Deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation.

  7. results show that ceramide acts at two distinct levels of the insulin (show INS Antibodies) signaling pathway (IRS1 (show IRS1 Antibodies) and Akt (show AKT1 Antibodies)). PKR, which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS Antibodies) resistance in muscle cells.

  8. Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 Antibodies) R) functions as negative regulator of PKR/Eif2ak2 (protein kinase (show CDK7 Antibodies) R) in development of postnatal anterior pituitary tissue.

  9. Data indicate increasing expression of PKR during TNF-a (show TNF Antibodies)-induced osteoclast formation. Its inhibition prevents TNF-a (show TNF Antibodies)-induced bone destruction in vivo and can be then considered as new therapeutic target for bone disease.

  10. The authors show that Murine cytomegalovirus m142 and m143 knockout mutants attain organ titers equivalent to those attained by wild-type virus in Pkr knockout mice.

EIF2AK2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with EIF2AK2

  • eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) antibody
  • eukaryotic translation initiation factor 2-alpha kinase 2 (eif2ak2) antibody
  • eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2) antibody
  • 2310047A08Rik antibody
  • 4732414G15Rik antibody
  • AI467567 antibody
  • AI747578 antibody
  • DKFZp469K1934 antibody
  • EIF2AK1 antibody
  • EIF2AK2 antibody
  • Pkr antibody
  • Prkr antibody
  • Tik antibody

Protein level used designations for EIF2AK2

double-stranded RNA-activated protein kinase , interferon-induced, double-stranded RNA-activated protein kinase , p68 kinase , P1/eIF-2A protein kinase , interferon-inducible RNA-dependent protein kinase , IFN-stimulated dsRNA-activated eIF2-alpha kinase 2 , double-stranded RNA activated protein kinase , eukaryotic translation initiation factor 2-alpha kinase 2 , double stranded RNA activated protein kinase , eIF-2A protein kinase 2 , interferon-inducible elF2alpha kinase , protein kinase, interferon-inducible double stranded RNA dependent , tyrosine-protein kinase EIF2AK2 , IFN- type I-induced and dsRNA-activated kinase , IFN-induced and double-stranded RNA-activated kinase , T-cell viral integration site , dsRNA-activated kinase , eIF-2 alpha , eukaryotic translation initiation factor 2 alpha kinase 2 , protein kinase RNA-activated , protein kinase, interferon inducible double stranded RNA dependent , serine/threonine-protein kinase TIK , Protein kinase, interferon-inducible double stranded RNA dependent

GENE ID SPECIES
395147 Gallus gallus
459155 Pan troglodytes
611397 Canis lupus familiaris
708912 Macaca mulatta
100001092 Danio rerio
100009013 Oryctolagus cuniculus
100147679 Equus caballus
100173054 Pongo abelii
100579484 Nomascus leucogenys
5610 Homo sapiens
19106 Mus musculus
54287 Rattus norvegicus
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