Browse our anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antibodies

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anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies (EIF2AK4)
On www.antibodies-online.com are 114 Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antibodies from 20 different suppliers available. Additionally we are shipping Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Proteins (7) and many more products for this protein. A total of 127 Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 products are currently listed.
Synonyms:
2610011M03, EIF2AK4, GCN2, Gcn2-like, MGCN2
list all antibodies Gene Name GeneID UniProt
EIF2AK4 440275 Q9P2K8
EIF2AK4 27103 Q9QZ05
EIF2AK4 114859  

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Most Popular Reactivities for anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antibodies

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Top referenced anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies

  1. Human Polyclonal EIF2AK4 Primary Antibody for IHC (p), WB - ABIN391197 : Lu, László, Miao, Chen, Wu: The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for 391197

  2. Human Polyclonal EIF2AK4 Primary Antibody for IP, WB - ABIN151140 : Rahmani, Davis, Crabtree, Habibi, Nguyen, Dent, Grant: The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. in Molecular and cellular biology 2007 (PubMed)

  3. Human Polyclonal EIF2AK4 Primary Antibody for IF (p), IHC (p) - ABIN684943 : Lehman, Ryeom, Koumenis: Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma. in Scientific reports 2015 (PubMed)

More Antibodies against Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Interaction Partners

Cow (Bovine) Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.

Human Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. Data show that siRNA-mediated depletion of general control nonderepressible 2 (GCN2) increases small RNA transcripts such as tRNA and 5S rRNA, and induces the p53 (show TP53 Antibodies) pathway activation.

  2. in response to vemurafenib, BRAF (show BRAF Antibodies)-mutated melanoma and colorectal cancer cells rapidly induced the ISR as a cytoprotective mechanism through activation of general control nonderepressible 2 (GCN2), an eIF2alpha (show EIF2A Antibodies) kinase sensing amino acid levels

  3. A novel homozygous EIF2AK4 mutation (c.257+4A>C) was identified in 1 of 9 (11.1%) patients diagnosed with HPAH. The novel EIF2AK4 mutation (c.257+4A>C) was homozygous in two sisters with severe pulmonary hypertension. None of the 72 patients with IPAH had biallelic EIF2AK4 mutations.

  4. A novel homozygous EIF2AK4 mutation (c.257+4A>C) was identified in 1 of 9 (11.1%) patients diagnosed with HPAH. The novel EIF2AK4 mutation (c.257+4A>C) was homozygous in two sisters with severe pulmonary hypertension. None of the 72 patients with IPAH had biallelic EIF2AK4 mutations.

  5. This is the first reported case of EIF2AK4 mutation in PVOD in a Chinese patient population. We found the frameshift EIF2AK4 mutation c.1392delT (p.Arg465fs) in this case.

  6. IDO (show IDO1 Antibodies), through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Antibodies), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Antibodies) and GLS2 (show GLS2 Antibodies)

  7. EIF2AK4 mutation was associated with pulmonary veno-occlusive disease. PVOD patients who were not significantly exposed to trichloroethylene were more likely to harbour EIF2AK4 mutations.

  8. Data show that sequenced eukaryotic translation initiation factor 2 alpha kinase 4 protein (EIF2AK4) with a homozygous mutation in all five families: c.3344C>T(p.P1115L).

  9. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  10. Upon deprivation of various amino acids, activated GCN2 up-regulates ATF4 (show ATF4 Antibodies) to induce expression of the stress response protein Sestrin2, which is required to sustain repression of mTORC1 by blocking its lysosomal localization

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. The data of this study suggest an important contribution of the General control non-derepressible 2 (GCN2) in T cell stress response to the resolution of autoimmune neuroinflammation.

  2. GCN2 activation increased phosphorylation of its substrate eIF2alpha (show EIF2A Antibodies) and the induction of the integrated stress response master regulator, ATF4 (show ATF4 Antibodies).

  3. GCN2 predisposes the exocrine pancreas to a maladaptive ER stress response and autophagy during asparaginase treatment.

  4. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.

  5. Dietary EAA sensing depends on physiologic need, but not GCN2.

  6. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  7. acute amino acid starvation suppressed intestinal inflammation via a mechanism dependent on GCN2; hence, results reveal a mechanism that couples amino acid sensing with control of intestinal inflammation via GCN2

  8. Gcn2 & Atf4 (show ATF4 Antibodies) are involved in L-proline metabolism regulation in embryonic stem cells.

  9. Metabolic stress signals delivered by GCN2 inhibit innate inflammatory responses to apoptotic cells, restricting adaptive immunity and preventing autoimmunity. GCN2 activation by halofunginone halobromide potently reduced autoimmune reactivity.

  10. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antigen Profile

Antigen Summary

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999

Alternative names and synonyms associated with Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4)

  • eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 4 (eif2ak4) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4) antibody
  • 2610011M03 antibody
  • EIF2AK4 antibody
  • GCN2 antibody
  • Gcn2-like antibody
  • MGCN2 antibody

Protein level used designations for EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4 , eukaryotic translation initiation factor 2-alpha kinase 4-like , GCN2 protein , GCN2 eIF2alpha kinase , GCN2-like protein , eukaryotic translation initiation factor 2-alpha kinase 4

GENE ID SPECIES
423285 Gallus gallus
453321 Pan troglodytes
478257 Canis lupus familiaris
513829 Bos taurus
100392095 Callithrix jacchus
579979 Strongylocentrotus purpuratus
100031798 Monodelphis domestica
100088614 Ornithorhynchus anatinus
100187226 Ciona intestinalis
100232582 Taeniopygia guttata
100358284 Oryctolagus cuniculus
100428309 Macaca mulatta
100552145 Anolis carolinensis
100606228 Nomascus leucogenys
100216307 Xenopus (Silurana) tropicalis
440275 Homo sapiens
27103 Mus musculus
114859 Rattus norvegicus
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