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anti-Human INSIG1 Antibodies:
anti-Mouse (Murine) INSIG1 Antibodies:
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Human Polyclonal INSIG1 Primary Antibody for ICC, IF - ABIN258396
Engelking, Liang, Hammer, Takaishi, Kuriyama, Evers, Li, Horton, Goldstein, Brown: Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. in The Journal of clinical investigation 2005
Show all 6 Pubmed References
Human Polyclonal INSIG1 Primary Antibody for WB - ABIN4892389
Roth, Looser, Kaufmann, Blättler, Rencurel, Huang, Moore, Meyer: Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. in Molecular pharmacology 2008
Our findings suggest that miR (show MLXIP Antibodies)-92a may affect cholesterol metabolism by repressing insig1, resulting in raised intracellular cholesterol levels and Golgi volume and hence enhanced protein secretion.
identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
Data show the essential role of PPARgamma (show PPARG Antibodies) and PPARgamma (show PPARG Antibodies) coactivator 1alpha (PGC-1alpha (show PPARGC1A Antibodies)) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36 (show CD36 Antibodies), and leading to cholesterol depletion in hepatocytes.
Our results indicated that the dysregulation of INSIG1 and SREBF1 (show SREBF1 Antibodies) caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group
No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 (show INSIG2 Antibodies) interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.
From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia.
Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.
These data suggest that p97 (show EIF4G2 Antibodies) recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes.
INSIG1 and p41 (show EPB41 Antibodies) Arp2 (show ACTR2 Antibodies)/3 complex (p41-Arc (show ARPC1B Antibodies))reduced expression might be involved in gastric cancer development or progression
INSIG-1 plays a role in regulating cholesterol concentration in human cells
In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.
myeloid-cell-specific Insig1-/- mice are more susceptible to HSV-1 infection
reducing Insig1 mRNA to a similar degree observed in morbidly obese human WAT accelerates adipocyte differentiation and enhances lipogenesis, and consequently, lipid accumulation
we consistently observe involvement of gp78 (show AMFR Antibodies) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (show AMFR Antibodies) or TRC8 (show RNF139 Antibodies) in the robust sterol-accelerated degradation of HMG-CoA reductase (show HMGCR Antibodies).
analysis of mRNA abundance and expression of SLC27A, ACC (show ACACA Antibodies), SCD (show SCD Antibodies), FADS, LPIN, INSIG, and PPARGC1 (show PPARGC1A Antibodies) gene isoforms in mouse mammary glands during the lactation cycle
insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes
the regulation of Insig-1 by PPARgamma (show PPARG Antibodies) agonists could in turn regulate SREBP processing and thus couple insulin (show INS Antibodies) sensitizers with the regulation of lipid homeostasis
IRS2 (show IRS2 Antibodies), HK2 (show HK2 Antibodies) and INSIG1 are direct targets of TFE3 (show TFE3 Antibodies)
Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR Antibodies) inhibitor lovastatin reduced sterol synthesis in Insig1-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.
Activation of CAR and PXR (show NR1I2 Antibodies) in mouse liver results in activation of Insig-1 along with reduced protein levels of the active form of sterol regulatory element binding protein 1 (Srebp-1 (show SREBF1 Antibodies)).
Insig-1 is a direct PPARdelta (show PPARD Antibodies) target gene in hepatocytes. PPARdelta (show PPARD Antibodies) inhibited SREBP-1 (show SREBF1 Antibodies) activation via induction of Insig-1. Overexpression of PPARdelta (show PPARD Antibodies) induced the expression of Insig-1, suppressed SREBP-1 (show SREBF1 Antibodies) activation, and ameliorated hepatic steatosis.
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
insulin induced gene 1
, insulin-induced gene 1 protein
, INSIG-1 membrane protein
, growth response protein (CL-6)
, immediate-early protein CL-6
, insulin-induced growth response protein CL-6