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Our findings suggest that miR (show MLXIP ELISA Kits)-92a may affect cholesterol metabolism by repressing insig1, resulting in raised intracellular cholesterol levels and Golgi volume and hence enhanced protein secretion.
identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
Data show the essential role of PPARgamma (show PPARG ELISA Kits) and PPARgamma (show PPARG ELISA Kits) coactivator 1alpha (PGC-1alpha (show PPARGC1A ELISA Kits)) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36 (show CD36 ELISA Kits), and leading to cholesterol depletion in hepatocytes.
Our results indicated that the dysregulation of INSIG1 and SREBF1 (show SREBF1 ELISA Kits) caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group
No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 (show INSIG2 ELISA Kits) interactions were found in the significant 3-locus and 4-locus gene-gene interaction models.
From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia.
Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans.
These data suggest that p97 (show EIF4G2 ELISA Kits) recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes.
INSIG1 and p41 (show EPB41 ELISA Kits) Arp2 (show ACTR2 ELISA Kits)/3 complex (p41-Arc (show ARPC1B ELISA Kits))reduced expression might be involved in gastric cancer development or progression
INSIG-1 plays a role in regulating cholesterol concentration in human cells
In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs.
myeloid-cell-specific Insig1-/- mice are more susceptible to HSV-1 infection
reducing Insig1 mRNA to a similar degree observed in morbidly obese human WAT accelerates adipocyte differentiation and enhances lipogenesis, and consequently, lipid accumulation
we consistently observe involvement of gp78 (show AMFR ELISA Kits) in Insig-1 degradation, we find no substantive evidence to support roles for either gp78 (show AMFR ELISA Kits) or TRC8 (show RNF139 ELISA Kits) in the robust sterol-accelerated degradation of HMG-CoA reductase (show HMGCR ELISA Kits).
analysis of mRNA abundance and expression of SLC27A, ACC (show ACACA ELISA Kits), SCD (show SCD ELISA Kits), FADS, LPIN, INSIG, and PPARGC1 (show PPARGC1A ELISA Kits) gene isoforms in mouse mammary glands during the lactation cycle
insig-1 expression restricts lipogenesis in mature adipocytes and blocks differentiation in preadipocytes
the regulation of Insig-1 by PPARgamma (show PPARG ELISA Kits) agonists could in turn regulate SREBP processing and thus couple insulin (show INS ELISA Kits) sensitizers with the regulation of lipid homeostasis
IRS2 (show IRS2 ELISA Kits), HK2 (show HK2 ELISA Kits) and INSIG1 are direct targets of TFE3 (show TFE3 ELISA Kits)
Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR ELISA Kits) inhibitor lovastatin reduced sterol synthesis in Insig1-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.
Activation of CAR and PXR (show NR1I2 ELISA Kits) in mouse liver results in activation of Insig-1 along with reduced protein levels of the active form of sterol regulatory element binding protein 1 (Srebp-1 (show SREBF1 ELISA Kits)).
Insig-1 is a direct PPARdelta (show PPARD ELISA Kits) target gene in hepatocytes. PPARdelta (show PPARD ELISA Kits) inhibited SREBP-1 (show SREBF1 ELISA Kits) activation via induction of Insig-1. Overexpression of PPARdelta (show PPARD ELISA Kits) induced the expression of Insig-1, suppressed SREBP-1 (show SREBF1 ELISA Kits) activation, and ameliorated hepatic steatosis.
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
insulin induced gene 1
, insulin-induced gene 1 protein
, INSIG-1 membrane protein
, growth response protein (CL-6)
, immediate-early protein CL-6
, insulin-induced growth response protein CL-6