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These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (show HMGCR ELISA Kits) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.
There may be a connection between INSIG2 expression and metastatic dissemination of colorectal cancer without any effect on tumorigenesis.
Insulin (show INS ELISA Kits) resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1 (show PFKFB1 ELISA Kits), PFKFB3 (show PFKFB3 ELISA Kits), and HK2 (show HK2 ELISA Kits) genes in the blood cells as compared to obese patients with normal insulin (show INS ELISA Kits) sensitivity.
Results confirmed that genetic variation in INSIG2 is associated with both overweight and LDL in non-Hispanic white children.
This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat.
INSIG2 is involved in adipogenesis and MC4R (show MC4R ELISA Kits) effects hormonal appetite control in response to the amount of adipose tissue.
The results provided evidence for identifying genetic factors of nonalcoholic fatty liver disease (NAFLD (show TSC2 ELISA Kits)) and may be useful for risk assessment and personalized medicine of NAFLD (show TSC2 ELISA Kits).
The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.
identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
Data show the essential role of PPARgamma (show PPARG ELISA Kits) and PPARgamma (show PPARG ELISA Kits) coactivator 1alpha (PGC-1alpha (show PPARGC1A ELISA Kits)) in up-regulating Insig-1 (show INSIG1 ELISA Kits)/2 expression, defining a mechanistic pathway triggered by CD36 (show CD36 ELISA Kits), and leading to cholesterol depletion in hepatocytes.
FASN (show FASN ELISA Kits) gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c (show SREBF1 ELISA Kits)-driven lipogenesis.
Data show that REV-ERBalpha (show NR1D1 ELISA Kits) participates in the circadian modulation of SREBP activity, and the expression of SREBP target genes involved in cholesterol and lipid metabolism via the cyclic transcription of Insig2.
Liver-specific mRNA for Insig-2 down-regulated by insulin (show INS ELISA Kits): implications for fatty acid synthesis.
a vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes
Insig2 identified as a strong candidate susceptibility gene for total plasma cholesterol levelsin inbred mice strains
Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR ELISA Kits) inhibitor lovastatin reduced sterol synthesis in Insig2-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.
A critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRalpha (show NR1H4 ELISA Kits) agonists or infected with constitutively active FXRalpha (show NR1H4 ELISA Kits).
Peroxisome deficiency causes a complex phenotype because of hepatic SREBP-1c (show SREBF1 ELISA Kits),-2/Insig-2a,b dysregulation associated with endoplasmic reticulum stress
Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 (show INSIG1 ELISA Kits) and insig-2 at an early phase in adipocyte differentiation.
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
insulin-induced gene 2 protein
, insulin-induced gene 2 protein-like
, insulin induced gene 2
, INSIG2 membrane protein
, insulin induced protein 2
, insulin-induced membrane protein 2
, INSIG-2 membrane protein
, Insulin-induced gene 2 protein