Browse our Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteins (PPP1R15A)

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Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Proteins (PPP1R15A)
On www.antibodies-online.com are 7 Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Proteins from 4 different suppliers available. Additionally we are shipping Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Antibodies (68) and Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Kits (2) and many more products for this protein. A total of 81 Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A products are currently listed.
Synonyms:
9630030H21, GADD34, Myd116, Peg-3, RGD1624209
list all proteins Gene Name GeneID UniProt
PPP1R15A 17872 P17564
PPP1R15A 23645 O75807
Rat PPP1R15A PPP1R15A 171071 Q6IN02

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More Proteins for Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A Interaction Partners

Mouse (Murine) Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) interaction partners

  1. Translation arrest is further demonstrated to be key for anti-viral response by acting synergistically with MAVS (show MAVS Proteins) activation to amplify TBK1 (show TBK1 Proteins) signaling and IFN-beta (show IFNB1 Proteins) mRNA transcription, while GADD34-dependent protein synthesis recovery contributes to the heterogeneous expression of interferon (show IFNA Proteins) observed in dsRNA-activated cells.

  2. Results highlighted the essential roles played by GADD34 and CReP (show PPP1R15B Proteins) in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress.

  3. Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 (show ZNF384 Proteins) is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress.

  4. Through aging or a high fat diet, insulin (show INS Proteins) signaling in GADD34-deficient liver converted to be down regulated compared with WT mice.

  5. Results show that GADD34 plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis involved in endoplasmic reticulum stress, reactive oxygen species production and autophagy formation.

  6. avidity for the substrate plays an important role in imparting specificity on the PPP1R15B-PP1G-actin ternary complex.

  7. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (show TLR4 Proteins) combined with amino acid deprivation through regulation of mTOR (show FRAP1 Proteins) signaling pathway in macrophages.

  8. GADD34 upregulated pro-inflammatory mediator.

  9. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2 (show SLC38A2 Proteins).

  10. GADD34 expression was upregulated in the liver of mice after exposure to a carcinogen, diethylnitrosamine (DEN). In both acute and chronic DEN treatment models, GADD34 deficiency not only decreased oncogene (show RAB1A Proteins) expression, but also reduced hepatic damage.

Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) interaction partners

  1. GADD34 constitutes a mechanistic link between endoplasmic reticulum stress and mTOR (show FRAP1 Proteins) inactivation, therefore promotes cell survival during endoplasmic reticulum stress.

  2. reduction of GADD34 expression significantly suppressed tumor, and resulted in decreased accumulation of MDSCs and T-cells, and inhibition of GADD34 reduced secretion of vascular epithelial growth factor alpha and transforming growth factor beta by MDSCs

  3. ANXA11 (show ANXA11 Proteins) rs1049550 and PPP1R15A rs557806 may improve the identification of mCRC patients sensitive to bevacizumab regimens, and further validation is required in large cohorts

  4. Data of this study strengthen the evidence of an unfolded protein response during the course of RA and provide an insight of the potential interest in GADD34 as a relevant marker for RA.

  5. The results suggest that dephosphorylation of eIF2a (show EIF2S1 Proteins) by GADD34 plays an important role in doxorubicin resistance of MCF-7/ADR (show AKR1B1 Proteins) cells.

  6. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (show NOX4 Proteins)) is induced downstream of ATF4 (show ATF4 Proteins), binds to a PP1 (show PPA1 Proteins)-targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 (show PPA1 Proteins) activity to increase eIF2alpha (show EIF2A Proteins) phosphorylation and ATF4 (show ATF4 Proteins) levels.

  7. stress pathways lead to the induction of the protein GADD34, which appears to provide protection against the toxic effects of the secreted virulence factors in Pseudomonas aeruginosa infection

  8. The data highlight independent interactions of PP1 (show PPA1 Proteins) and eIF2alpha (show EIF2A Proteins) with GADD34, demonstrating that GADD34 functions as a scaffold both in vitro and in cells

  9. GADD34 may play a neuroprotective role against amyloid-beta toxicity.

  10. GADD34 enhances autophagy and suppresses apoptosis stimulated by LPS (show IRF6 Proteins) combined with amino acid deprivation through regulation of mTOR (show FRAP1 Proteins) signaling pathway in macrophages.

Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A) Protein Profile

Protein Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

Alternative names and synonyms associated with Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A)

  • protein phosphatase 1, regulatory subunit 15A (PPP1R15A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A)
  • protein phosphatase 1, regulatory (inhibitor) subunit 15A (Ppp1r15a)
  • protein phosphatase 1, regulatory subunit 15A (Ppp1r15a)
  • 9630030H21 protein
  • GADD34 protein
  • Myd116 protein
  • Peg-3 protein
  • RGD1624209 protein

Protein level used designations for PPP1R15A

protein phosphatase 1, regulatory (inhibitor) subunit 15A , growth arrest and DNA damage-inducible protein GADD34 , growth arrest and DNA-damage-inducible 34 , myeloid differentiation primary response gene 116 , myeloid differentiation primary response protein MyD116 , protein phosphatase 1 regulatory subunit 15A , myeloid differentiation primary response protein MyD116 homolog , progression elevated gene 3 protein

GENE ID SPECIES
456191 Pan troglodytes
718350 Macaca mulatta
100449481 Pongo abelii
100591446 Nomascus leucogenys
17872 Mus musculus
23645 Homo sapiens
171071 Rattus norvegicus
514688 Bos taurus
476419 Canis lupus familiaris
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