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CReP expression was markedly suppressed in XBP1 (show XBP1 Proteins)-deficient mice livers due to hyperactivated Ire1alpha (show ERN1 Proteins).
Ppp1r15a (show PPP1R15A Proteins) mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality
Whole-exome sequencing identified a homozygous missense mutation, c.1972G>A; p.Arg658Cys, in protein phosphatase 1 (show PPP1CB Proteins), regulatory subunit 15b (PPP1R15B)
the first homozygous mutation in the PPP1R15B gene encoding the regulatory subunit of an eIF2alpha (show EIF2A Proteins)-specific phosphatase in two siblings affected by a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly
CIP2A (show KIAA1524 Proteins) regulates cancer metabolism and CREB (show CREB1 Proteins) phosphorylation in non-small cell lung cancer
the mammalian traffic machinery co-opts p-eIF2alpha (show EIF2A Proteins) and CReP, regulators of translation initiation.
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1\; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009
constitutive repressor of eIF2alpha phosphorylation
, protein phosphatase 1 regulatory subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15b