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Browse our anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Antibodies

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anti-Synovial Apoptosis Inhibitor 1, Synoviolin Antibodies (SYVN1)
On are 101 Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Antibodies from 18 different suppliers available. Additionally we are shipping Synovial Apoptosis Inhibitor 1, Synoviolin Proteins (7) and Synovial Apoptosis Inhibitor 1, Synoviolin Kits (3) and many more products for this protein. A total of 129 Synovial Apoptosis Inhibitor 1, Synoviolin products are currently listed.
1200010C09Rik, AW211966, C85322, D530017H19Rik, DER3, Hrd1, RGD1310488
list all antibodies Gene Name GeneID UniProt
SYVN1 84447 Q86TM6
SYVN1 74126 Q9DBY1
SYVN1 361712  

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Top referenced anti-Synovial Apoptosis Inhibitor 1, Synoviolin Antibodies

  1. Human Polyclonal SYVN1 Primary Antibody for IF, IHC (p) - ABIN388980 : Kaneko, Koike, Saito, Kitamura, Okuma, Nomura: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)
    Show all 11 references for ABIN388980

  2. Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN250959 : Soundararajan, Wang, Melters, Pearce: Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. in The Journal of biological chemistry 2010 (PubMed)
    Show all 7 references for ABIN250959

  3. Human Polyclonal SYVN1 Primary Antibody for WB - ABIN1882139 : Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. in The Journal of biological chemistry 2004 (PubMed)
    Show all 6 references for ABIN1882139

  4. Human Polyclonal SYVN1 Primary Antibody for WB - ABIN650702 : Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. in Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)
    Show all 3 references for ABIN650702

  5. Human Polyclonal SYVN1 Primary Antibody for IHC (fro), IF (p) - ABIN671811 : Yan, Zheng, Chen, Liu, Li, Hu, Pei, Li: Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats. in Experimental diabetes research 2011 (PubMed)
    Show all 2 references for ABIN671811

  6. Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN4319847 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

  7. Cow (Bovine) Polyclonal SYVN1 Primary Antibody for WB - ABIN2774800 : Cattaneo, Otsu, Fagioli, Martino, Lotti, Sitia, Biunno: SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. in Journal of cellular physiology 2008 (PubMed)

  8. Human Polyclonal SYVN1 Primary Antibody for ELISA, IHC - ABIN4319849 : Kaneko: [Possible involvement of HRD1 (ubiquitin E3 ligase) in neurodegenerative diseases]. in Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2009 (PubMed)

  9. Human Polyclonal SYVN1 Primary Antibody for EIA, IHC (p) - ABIN357625 : Yamada, Ishihara, Tamura, Takahashi, Yamaguchi, Takei, Tokita, Satake, Tashiro, Katagiri, Aburatani, Miyazaki, Oka: WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. in Human molecular genetics 2006 (PubMed)

More Antibodies against Synovial Apoptosis Inhibitor 1, Synoviolin Interaction Partners

Human Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) interaction partners

  1. Analysis of affinity-captured Hrd1 complexes from these cells by size-exclusion chromatography, immunodepletion, and absolute quantification mass spectrometry identified two major high-molecular-mass complexes with distinct sets of interacting proteins and variable stoichiometries, suggesting a hitherto unrecognized heterogeneity in the functional units of Hrd1-mediated protein degradation.

  2. This study provides new knowledge of the CFTR (show CFTR Antibodies) biosynthetic pathway. It suggests that SYVN1 and FBXO2 (show FBXO2 Antibodies) represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR (show CFTR Antibodies) in airway epithelia and identifies a new role for NEDD8 (show NEDD8 Antibodies) in regulating DeltaF508-CFTR (show CFTR Antibodies) ubiquitination.

  3. Study shows that mir125b is up-regulated in osteoarthritis (OA) and inversely correlated with SYNV1 expression. Also, findings demonstrated that miR (show MLXIP Antibodies)- 125b-5p could promote apoptosis of synovial cells through targeting the SYVN1 gene, and the excessive apoptosis of synovial cells could contribute to the development of OA.

  4. HRD1 is a novel substrate for USP19 (show USP19 Antibodies). USP19 (show USP19 Antibodies) negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation.

  5. Prion protein (show PRNP Antibodies) mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP (show GDF10 Antibodies).

  6. OS-9 (show OS9 Antibodies), an ER-resident lectin, acts downstream of Grp94 (show HSP90B1 Antibodies) to further recognize misfolded alpha1 subunits in a glycan-dependent manner. This delivers misfolded alpha1 subunits to the Hrd1-mediated ubiquitination and the valosin-containing protein (show vcp Antibodies)-mediated extraction pathway.

  7. These findings uncover a novel role for HRD1 in breast cancer.

  8. The inherently unstable nature of the human SEL1L (show SEL1L Antibodies) protein lies in its transmembrane domain, and that association of HRD1 with the SEL1L (show SEL1L Antibodies) transmembrane domain restored its stability.

  9. specific silencing of Derlin-2 (show DERL2 Antibodies), p97 (show EIF4G2 Antibodies) and HRD1 by shRNAs increases steady state levels of proinsulin (show INS Antibodies). these ERAD constituents are critically involved in proinsulin (show INS Antibodies) degradation and may therefore also play a role in subsequent antigen generation.

  10. Charcot-Marie-Tooth disease-related PMP22 (show PMP22 Antibodies) is trapped in the endoplasmic reticulum by calnexin (show CANX Antibodies)-dependent retention and Rer1 (show RER1 Antibodies)-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system.

Mouse (Murine) Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) interaction partners

  1. SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.

  2. Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  3. Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.

  4. The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC Antibodies)-1b.

  5. Data indicate that E3 ubiquitin-protein ligase (show UBE2K Antibodies) Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1 (show PRDM1 Antibodies)) to promote MHC-II antigen expression.

  6. oxidative stress-induced (show SQSTM1 Antibodies) HRD1 insolubilization might be involved in a vicious cycle of increased amyloid beta production and amyloid beta-induced oxidative stress in Alzheimer's disease pathogenesis.

  7. results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A Antibodies) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis

  8. Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1 (show RER1 Antibodies), for degradation.

  9. HRD1 is colocated with the neural stem cell marker protein nestin (show NES Antibodies) and glial fibrillary acidic protein (show GFAP Antibodies) in the endoplasmic reticulum membrane of the NSCs of the subventricular zone (SVZ astrocytes) but in the cell nucleus of in the dentate gyrus

  10. these results clearly suggest that both beta-TrCP (show BTRC Antibodies)- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Antibodies) to maintain cellular homeostasis.

Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Antigen Profile

Antigen Summary

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.

Alternative names and synonyms associated with Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1)

  • synovial apoptosis inhibitor 1, synoviolin (syvn1) antibody
  • synovial apoptosis inhibitor 1, synoviolin (SYVN1) antibody
  • synovial apoptosis inhibitor 1, synoviolin (Syvn1) antibody
  • 1200010C09Rik antibody
  • AW211966 antibody
  • C85322 antibody
  • D530017H19Rik antibody
  • DER3 antibody
  • Hrd1 antibody
  • RGD1310488 antibody

Protein level used designations for SYVN1

E3 ubiquitin-protein ligase synoviolin , synovial apoptosis inhibitor 1, synoviolin , HMG-coA reductase degradation 1 homolog , synoviolin 1 , HRD1 protein

100327246 Xenopus (Silurana) tropicalis
100514334 Sus scrofa
100581754 Nomascus leucogenys
84447 Homo sapiens
483746 Canis lupus familiaris
508358 Bos taurus
74126 Mus musculus
361712 Rattus norvegicus
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