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Human Polyclonal SYVN1 Primary Antibody for IF, IHC (p) - ABIN388980
Kaneko, Koike, Saito, Kitamura, Okuma, Nomura: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 11 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN250959
Soundararajan, Wang, Melters, Pearce: Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. in The Journal of biological chemistry 2010
Show all 8 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN1882139
Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. in The Journal of biological chemistry 2004
Show all 6 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN650702
Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. in Journal of immunology (Baltimore, Md. : 1950) 2013
Show all 3 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for IHC (fro), IF (p) - ABIN671811
Yan, Zheng, Chen, Liu, Li, Hu, Pei, Li: Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats. in Experimental diabetes research 2011
Show all 2 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for ELISA, IHC - ABIN4319849
Kaneko: [Possible involvement of HRD1 (ubiquitin E3 ligase) in neurodegenerative diseases]. in Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2009
Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN4319847
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Results demonstrated that overexpression of Hrd1 increased the proteasomal degradation and microtubule-dependent aggresome formation of OPTN (show OPTN Antibodies) in the microtubular organizing center, whereas knockdown of Hrd1 stabilized OPTN (show OPTN Antibodies) and inhibited aggresome formation of OPTN (show OPTN Antibodies).
Data show that E3 ubiquitin ligase (show MUL1 Antibodies) HRD1 (HRD1) decreased the protein level of S100A8 (show S100A8 Antibodies) through ubiquitination.
Analysis of affinity-captured Hrd1 complexes from these cells by size-exclusion chromatography, immunodepletion, and absolute quantification mass spectrometry identified two major high-molecular-mass complexes with distinct sets of interacting proteins and variable stoichiometries, suggesting a hitherto unrecognized heterogeneity in the functional units of Hrd1-mediated protein degradation.
This study provides new knowledge of the CFTR (show CFTR Antibodies) biosynthetic pathway. It suggests that SYVN1 and FBXO2 (show FBXO2 Antibodies) represent two distinct multiprotein complexes that may degrade DeltaF508-CFTR (show CFTR Antibodies) in airway epithelia and identifies a new role for NEDD8 (show NEDD8 Antibodies) in regulating DeltaF508-CFTR (show CFTR Antibodies) ubiquitination.
Study shows that mir125b is up-regulated in osteoarthritis (OA) and inversely correlated with SYNV1 expression. Also, findings demonstrated that miR (show MLXIP Antibodies)- 125b-5p could promote apoptosis of synovial cells through targeting the SYVN1 gene, and the excessive apoptosis of synovial cells could contribute to the development of OA.
HRD1 is a novel substrate for USP19 (show USP19 Antibodies). USP19 (show USP19 Antibodies) negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation.
Prion protein (show PRNP Antibodies) mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP (show GDF10 Antibodies).
OS-9 (show OS9 Antibodies), an ER-resident lectin, acts downstream of Grp94 (show HSP90B1 Antibodies) to further recognize misfolded alpha1 subunits in a glycan-dependent manner. This delivers misfolded alpha1 subunits to the Hrd1-mediated ubiquitination and the valosin-containing protein (show vcp Antibodies)-mediated extraction pathway.
These findings uncover a novel role for HRD1 in breast cancer.
The inherently unstable nature of the human SEL1L (show SEL1L Antibodies) protein lies in its transmembrane domain, and that association of HRD1 with the SEL1L (show SEL1L Antibodies) transmembrane domain restored its stability.
SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.
The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC Antibodies)-1b.
Data indicate that E3 ubiquitin-protein ligase (show UBE2K Antibodies) Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1 (show PRDM1 Antibodies)) to promote MHC-II antigen expression.
oxidative stress-induced (show SQSTM1 Antibodies) HRD1 insolubilization might be involved in a vicious cycle of increased amyloid beta production and amyloid beta-induced oxidative stress in Alzheimer's disease pathogenesis.
results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A Antibodies) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis
Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1 (show RER1 Antibodies), for degradation.
HRD1 is colocated with the neural stem cell marker protein nestin (show NES Antibodies) and glial fibrillary acidic protein (show GFAP Antibodies) in the endoplasmic reticulum membrane of the NSCs of the subventricular zone (SVZ astrocytes) but in the cell nucleus of in the dentate gyrus
these results clearly suggest that both beta-TrCP (show BTRC Antibodies)- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Antibodies) to maintain cellular homeostasis.
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
E3 ubiquitin-protein ligase synoviolin
, synovial apoptosis inhibitor 1, synoviolin
, HMG-coA reductase degradation 1 homolog
, synoviolin 1
, HRD1 protein