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TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man.
the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C (show KDM5C ELISA Kits) and IQSEC2 (show IQSEC2 ELISA Kits), is reported.
homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 (show LRP2 ELISA Kits) and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability
Authors demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB (show NFKB1 ELISA Kits) signaling by deactivating IkappaB kinase (show CHUK ELISA Kits) (IKK (show CHUK ELISA Kits)) complex.
TSPYL2 is an essential component of the REST/NRSF (show REST ELISA Kits) transcriptional complex for TGFbeta (show TGFB1 ELISA Kits) signaling activation
The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC (show FAM126A ELISA Kits) and related liver cancers in male-biased manners.
More importantly, RPS14 (show RPS14 ELISA Kits) was specifically modified with NEDD8 (show NEDD8 ELISA Kits) and hCINAP inhibited RPS14 (show RPS14 ELISA Kits) NEDDylation by recruiting NEDD8-specific protease 1 (show SENP8 ELISA Kits)
TSPX is principally expressed in Sertoli cells in the human testis.
knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability
Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development.
These findings suggest that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits.
Following infection with T. gondii, myotubes but not myoblasts or fibroblasts further upregulate the negative cell cycle regulator Tspyl2.
We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a (show GRIN2A ELISA Kits) and Grin2b (show GRIN2B ELISA Kits).
CDA1 deletion reduces but does not block renal TGF-beta (show TGFB1 ELISA Kits) signaling.
TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition.
DENTT may play a role in development of the endocrine tissues, nervous system, lung, oocytes, and thecal cells, and testis [DENTT]
DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation.
Mice treated with hypertonic saline expressed higher CINAP protein levels in the PVN, supporting a role of CINAP in neural response in vivo.
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
, testis-specific Y-encoded protein 2
, testis-specific Y-encoded protein Q1
, CASK-interacting nucleosome assembly protein
, CTCL tumor antigen se20-4
, CTCL-associated antigen se20-4
, TSPY-like protein 2
, cell division autoantigen 1
, cutaneous T-cell lymphoma-associated antigen se20-4
, cutaneous T-cell lymphoma-associated tumor antigen se20-4
, differentially expressed nucleolar TGF-beta1 target
, differentially-expressed nucleolar TGF-beta1 target protein
, nuclear protein of 79 kDa
, testis-specific Y-encoded-like protein 2
, testis-specific protein Y encoded-like 2
, CASK interacting nucleosome assembly protein
, cell division autoantigen 1 nucleolar protein
, nucleolar TGF-beta1 target protein