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anti-Human YOD1 Antibodies:
anti-Rat (Rattus) YOD1 Antibodies:
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Human Polyclonal YOD1 Primary Antibody for IF, IHC (p) - ABIN655251
Ernst, Mueller, Ploegh, Schlieker: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. in Molecular cell 2009
Show all 2 Pubmed References
These data define that YOD1 antagonizes TRAF6 (show TRAF6 Antibodies)/p62 (show GTF2H1 Antibodies)-dependent IL-1 (show IL1A Antibodies) signaling to NF-kappaB (show NFKB1 Antibodies).
Upon damage, p97 (show EIF4G2 Antibodies) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1 (show UBXN6 Antibodies), PLAA (show PLAA Antibodies), and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response.
activity of the p97 (show EIF4G2 Antibodies)-associated deubiquitinylase YOD1 is also required for substrate disposal
miR (show MLXIP Antibodies)-373 increases proliferation by directly targeting YOD1 in cervical cancer.
The assignment of a p97 (show EIF4G2 Antibodies)-associated ubiquitin processing function to YOD1 adds to our understanding of p97 (show EIF4G2 Antibodies)'s role in the dislocation of misfolded proteins from the endoplasmic reticulum.
Antigen presenting cells (APCs (show APCS Antibodies)) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8 (show CD8A Antibodies)(+) T cells, both in vitro and in vivo.
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants.
, HIV-1-induced protease 7
, OTU domain containing 2
, OTU domain-containing protein 2
, YOD1 OTU deubiquinating enzyme 1 homolog ( yeast)
, ubiquitin thioesterase OTU1
, HIV-induced protein-7-like protease
, YOD1 OTU deubiquinating enzyme 1 homolog
, YOD1 OTU deubiquitinating enzyme 1 homologue