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Human BTK ELISA Kit for Cell ELISA - ABIN2683573
Guo, Liu, Bhardwaj, Yang, Changou, Ma, Mazloom, Chintapalli, Xiao, Xiao, Kumaresan, Sanchez, Yeh, Evans, Patterson, Lam, Kung: Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. in Cell death & disease 2014
Resistant BTK mutants reconstituted B cell receptor-triggered chemokine (show CCL1 ELISA Kits) secretion in the presence of corresponding inhibitors, demonstrating that BTK activity is connected with cell-intrinsic functions of malignant B cells with importance for their dialogue with the micro-environment.
Bone marrow mesenchymal stem cells could increase myeloma stemness via activation of the BTK signal pathway.
the results show that the interaction between BTK and ANKRD54 is highly selective, since it was also identified in a screen using human SH3-domainome. A novel finding is that BTK not only binds to ANKRD54, but stands out as the preferred interactor, being highly dominant over all other human SH3-domains.
this study elucidated mechanisms of BCL2 (show BCL2 ELISA Kits) overexpression and association of this survival pathway with the BCR (show BCR ELISA Kits)/BTK signaling pathway in MCL (show FH ELISA Kits), and revealed the role of BTK in noncanonical NF-kappaB (show NFKB1 ELISA Kits) activation, which also promotes cancer cell survival.
BTK, via p65BTK expression, is a novel and powerful oncogene (show RAB1A ELISA Kits) acting downstream of the RAS/MAPK (show MAPK1 ELISA Kits) pathway and suggest that its targeting may be a promising therapeutic approach.
We conclude that despite being involved in oncogenic signals in blood malignancies, BTK has antineoplastic properties in other contexts, such as the enhancement of p53 (show TP53 ELISA Kits)'s tumor suppressor responses
Inhibition of Btk by inhalation of aerosolized RN983 may be effective as a stand-alone asthma therapy.
LMP2A signaling results in STAT3 (show STAT3 ELISA Kits) phosphorylation in B cells through a PI3K (show PIK3CA ELISA Kits)/BTK-dependent pathway.
Case Report: Btk mutation responsible for X-Linked agammaglobulinemia manifesting as Pseudomonas aeruginosa liver abscess.
this review describes contributions of BTK to immune tolerance, including studies testing BTK-inhibitors for treatment of autoimmune diseases
Rictor (show RICTOR ELISA Kits) positively regulates B cell receptor signaling via up-regulating Btk and down-regulating SH2-containing inositol phosphatase (show INPP5D ELISA Kits)
The pre-B-cell receptor (pre-BCR (show BCR ELISA Kits)) signaling molecules BLNK (show BLNK ELISA Kits), BTK and BANK1 (show BANK1 ELISA Kits) were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR (show BCR ELISA Kits) signaling pathway.
these data indicate that in mature B cells, Tec (show NR4A3 ELISA Kits) and Btk may compete for activation of the Akt (show AKT1 ELISA Kits) signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec (show NR4A3 ELISA Kits) kinase.
these data demonstrate that enhanced BTK signaling in B cells can establish a T cell-driven proinflammatory loop resulting in autoimmune pathology, making BTK inhibition an attractive therapeutic strategy
Btk and NLRP3 (show NLRP3 ELISA Kits) co-regulate platelet activation, aggregation, and in vitro thrombus formation.The NLRP3 (show NLRP3 ELISA Kits) inflammasome is upregulated in activated platelets.
Btk inhibition ameliorated hepatocellular injury in a well-established model of liver partial warm ischemia and in situ reperfusion.
report that BTK is expressed by murine and human MDSCs, and that ibrutinib is able to inhibit BTK phosphorylation in these cells
ITK (show ITK ELISA Kits) and BTK regulate thermal homeostasis during septic response through mast cell function in mice.
Btk inhibition treats TLR7 (show TLR7 ELISA Kits)/IFN driven murine lupus
inositol hexakisphosphate (IP6), a soluble signaling molecule found in both animal and plant cells, also activates Btk.
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.
Bruton agammaglobulinemia tyrosine kinase
, B-cell progenitor kinase
, agammaglobulinaemia tyrosine kinase
, dominant-negative kinase-deficient Brutons tyrosine kinase
, tyrosine-protein kinase BTK
, tyrosine-protein kinase BTK isoform (lacking exon 14)
, Bruton's tyrosine kinase
, Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)
, X-linked immune deficiency
, agammaglobulinemia tyrosine kinase
, bruton tyrosine kinase
, kinase EMB