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Two infants with relapsed, refractory B-cell acute lymphoblastic leukemia went into complete remission after being treated with CD19-targeting CAR T cells derived from an unmatched donor
These data provide proof-of-principle for the view that newly generated Ab-secreting cells can acquire a mature plasma cell phenotype that is accompanied by loss of CD19 expression at an early stage of differentiation and that aging is not an obligate requirement for a CD19(neg) state to be established.
Results indicate the strong efficacy of FLAG-tagged CD19 CAR-T cells in solid and hematological cancer models.
The histological observations suggested that the patients represent diverse cases of NHL (show RTEL1 ELISA Kits) like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL (show RTEL1 ELISA Kits). The findings indicate that patients with NHL (show RTEL1 ELISA Kits) may also be analyzed for status of PAX5 (show PAX5 ELISA Kits), CD19 and ZAP70 (show ZAP70 ELISA Kits), and their transcriptional and post-translational variants for the differential diagnosis of NHL (show RTEL1 ELISA Kits) and therapy.
The frequencies of CD19+CD24hiCD38hi B-regulatory lymphocyte were significantly increased in children with beta-thalassemia.
a CD45 (show PTPRC ELISA Kits)+/CD19 - cell population in bone marrow aspirates correlated with the clinical outcome of patients with mantle cell lymphoma.
CD19 is required for TLR9 (show TLR9 ELISA Kits)-induced B-cell activation (show BLNK ELISA Kits). Hence CD19/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits)/BTK (show BTK ELISA Kits) is an essential axis integrating BCRs and TLR9 (show TLR9 ELISA Kits) signaling in human B cells.
High anti-EBV IgG levels in Crohn's disease are associated with 5-aminosalicylic acid treatment, tonsillectomy, and decrease of CD19(+) cells.
We propose that CD81 (show CD81 ELISA Kits) enables the maturation of CD19 and its trafficking to the membrane by regulating the exit of CD19 from the ER to the pre-Golgi compartment
we outline our approach to nonviral gene transfer using the Sleeping Beauty system and the selective propagation of CD19-specific CAR(+) T cells on AaPCs
This study demonstrates that antiviral protective antibody-secreting cells (ASC (show STS ELISA Kits)) in the central nervous system are dependent on CD19 activation and peripheral Germinal Center formation, while accumulation of early-recruited IgD(+) B cells is CD19 independent.
this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells
autoimmunity induced by excessive BAFF (show TNFSF13B ELISA Kits) production requires B1b B cells and CD19 signaling.
WIPF1 (show WIPF1 ELISA Kits) deficiency impaired CD19 co-receptor activation and subsequent PI3 kinase (show PIK3CA ELISA Kits) signaling, by distorting the actin and tetraspanin networks that lead to altered CD19 cell surface dynamics.
Syk (show SYK ELISA Kits)-deficient B cells require BAFF receptor (show TNFRSF13C ELISA Kits) and CD19/PI3K signaling for their long-term survival.
The selection of mature B cells is critically dependent on the expression level of the co-receptor CD19.
This inhibitory function of FcgammaRIIB in impairing the spatial-temporal colocalization of BCR (show BCR ELISA Kits) and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus
These results show that the ability of CD19-CAR T-cells to home in on tumor lesions is pivotal for their anti-tumor effects in our xenograft models, and therefore may enhance the efficacy of adoptive T-cell therapy for refractory B-cell lymphoma.
Data show that effective B cell receptor (BCR (show BCR ELISA Kits)) signaling requires collaboration with the coreceptor CD19 organized by the CD81 (show CD81 ELISA Kits)-tetraspanin network.
results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes
DNA sequence analysis of the coding sequence of CD19, the CR2 co-signaling molecule.
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
B-lymphocyte antigen CD19
, B-lymphocyte surface antigen B4
, T-cell surface antigen Leu-12
, differentiation antigen CD19
, CD19 antigen
, B cell surface marker CD19
, CD19 molecule
, b-lymphocyte antigen CD19-like
, Differentiation antigen CD19