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Autoreactive CD4 (show CD4 Proteins)(+) T cells that target FcepsilonRIalpha were detected in most subjects with chronic spontaneous urticaria, with a cytokine secretion profile more typical of a TH1 (show TH1L Proteins)-cell response. Our findings suggest that measurement of T-cell as well as autoantibody responses to FcepsilonRIalpha could improve diagnostic accuracy in subjects with chronic spontaneous urticaria .
Our results suggest that IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108, four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children.
F-AFE containing anti-allergic phytochemicals, including arctigenin, inhibited the activation of the FceRI receptor induced by the antigenIgE complex
IgG2 and IgG3 are involved in recruiting CD32 to inhibit activation of FcepsilonRI (show FCER1G Proteins) in human basophils.
Asthmatics with reduced lung function had a higher frequency of Lin(-) CD34 (show CD34 Proteins)(hi) CD117(int/hi) Fc epsilon RI(+) blood mast cell progenitors than asthmatics with normal lung function.
SNPs of FcepsilonR1alpha promoter region may be used as disease markers for IgE-mediated allergic inflammation caused by Dermatophagoides pteronyssinus.
FcepsilonRI (show FCER1G Proteins) alpha-chain (show FCGRT Proteins) is an activating platelet endothelium aggregation receptor 1 (PEAR1 (show PEAR1 Proteins)) ligand.
Tetraspanin CD151 (show CD151 Proteins) Is a Negative Regulator of FcepsilonRI (show FCER1G Proteins)-Mediated Mast Cell Activation
FCER2 (show FCER2 Proteins) polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of FCER1A SNP rs2427837.
Data indicate that antigen (Ag) targeting to FcepsilonRI (show FCER1G Proteins) inhibits the development of Ag-specific T cell immunity and induces T cell tolerance.
this study shows that mast cells co-cultured with macrophages alter protein expression of both cell types, and that mast cells transfer FceRI-encompassed cellular regions directly to macrophages during Francisella tularensis
Tim-3 (show HAVCR2 Proteins) acts at a receptor-proximal point to enhance Lyn (show LYN Proteins) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI ligation.
Data indicate that white adipose tissue from IgE receptor FcR1-deficient Fcer1a(-/-) mice showed an increased expression of CCAAT-enhancer-binding protein-alpha (C-EBPalpha (show CEBPA Proteins)) and peroxisome proliferator-activated receptor-gamma (PPARgamma (show PPARG Proteins)).
Conferring expression of FcepsilonRI to dendritic cells decreases the severity of food allergy and asthma in disease-relevant models suggesting anti-inflammatory IgE/FcepsilonRI signals.
IgE-mediated activation of dendritic cells via IgE receptors binding in allergic Th2-type inflammation appears to be immune regulatory rather than pro-inflammatory. (Review)
Tetraspanin CD151 (show CD151 Proteins) Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation
IgE-mediated allergic hypersensitivity provokes release of renin (show REN Proteins) from both cultured and resident cardiac mast cells.
CD72 (show CD72 Proteins) negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha.
Zinc-binding MT1 (show MT1 Proteins) and MT2 are key modulators of Fc epsilonRI-induced basophil production of IL-4 (show IL4 Proteins).
Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI.
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
, high affinity immunoglobulin epsilon receptor subunit alpha
, Fc IgE receptor, alpha polypeptide
, Fc epsilon RI alpha-chain
, Fc-epsilon RI-alpha
, high affinity immunoglobulin epsilon receptor alpha-subunit
, igE Fc receptor subunit alpha
, immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
, Fc receptor, IgE, high affinity I, alpha polypeptide
, alpha polypeptide
, fc-epsilon RI-alpha