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anti-Human HCLS1 Antibodies:
anti-Mouse (Murine) HCLS1 Antibodies:
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Human Monoclonal HCLS1 Primary Antibody for IF, IP - ABIN968027
Fukuda, Kitamura, Taniuchi, Maekawa, Benhamou, Sarthou, Watanabe: Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate. in Proceedings of the National Academy of Sciences of the United States of America 1995
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Human Monoclonal HCLS1 Primary Antibody for IF, ELISA - ABIN561238
Kan, Wen, Pasquier, Jankowski, Chang, Richards, Kavallaris, MacKenzie: Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization. in Oncogene 2012
Human Monoclonal HCLS1 Primary Antibody for IF, IP - ABIN968026
Takemoto, Furuta, Li, Strong-Sparks, Hashimoto: LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck. in The EMBO journal 1995
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Cow (Bovine) Polyclonal HCLS1 Primary Antibody for IHC, WB - ABIN2777502
Ruzzene, Penzo, Pinna: Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. in The Biochemical journal 2002
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Cow (Bovine) Polyclonal HCLS1 Primary Antibody for IHC, WB - ABIN2777503
Barcroft: The Oxygen Tension in the Submaxillary Glands and certain other tissues. in The Biochemical journal 2006
Show all 2 Pubmed References
HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation.
Results identified two proteins P23 (show CDK5R1 Antibodies) and HCLS1, which were not known as RNA-binding proteins, exhibiting RNA-binding activity.
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 (show PAK1 Antibodies) and Ezrin (show EZR Antibodies) in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 (show FLT3 Antibodies) receptors.
studies show that HS1 promotes an early step in the endocytic pathway that is required for efficient Ag presentation of exogenous Ag by dendritic cells
Studies show that HS1 functions in concert with WASp to fine-tune DC cytoarchitecture and direct cell migration.
In vivo, immunodeficient Rag2 (show RAG2 Antibodies)(-/-)gamma(c)(-/-) mice injected with HS1-silenced CLL B cells showed a decreased organ infiltration with the notable exception of the bone marrow.
Hematopoietic lineage cell specific protein 1 (show SP1 Antibodies) plays a significant functional role in platelet activation downstream of glycoprotein VI and protease-activated receptors[Hematopoietic lineage cell specific protein 1 (show SP1 Antibodies)]
data indicate that Syk (show SYK Antibodies) kinase plays an important role in the translocation of hematopoietic lineage cell-specific protein 1 (show SP1 Antibodies) (HS1) into lipid rafts
This study concludes that HS1 does not play a major role in platelet function. It is possible that a role for HS1 is masked by the presence of cortactin (show CTTN Antibodies).
tyrosine phosphorylation of HS1 occurs downstream of both PAR-1 (show MARK2 Antibodies) and PAR-4 (show F2RL3 Antibodies). HS1 phosphorylation is a Gq mediated response regulated by Src (show SRC Antibodies) kinases
Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 (show MMP2 Antibodies) and MMP9 (show MMP9 Antibodies) through PI3 kinase (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells.
These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 (show PPARG Antibodies) regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
SDF1alpha-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.
miR (show MLXIP Antibodies)-152 controls both the expression of 14-3-3beta and HLA-G (show HLAG Antibodies) and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT (show PARP1 Antibodies), APAF1 (show APAF1 Antibodies), BCL2 (show BCL2 Antibodies), BAD, BID (show BID Antibodies), MCL1 (show MCL1 Antibodies), BIRC4 (show XIAP Antibodies), BCL2L1 (show BCL2L1 Antibodies), ENDOG (show ENDOG Antibodies), YWHAB (show YWHAB Antibodies), and YWHAQ (show YWHAQ Antibodies), influence promoter activity in an allele-specific manner.
Crystal structure of Myo1c (show MYO1C Antibodies)/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin (show INS Antibodies)-stimulated glucose uptake.
Data identified three classes of 14-3-3 (show YWHAQ Antibodies) targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
These results indicate that the six YWHAB (show YWHAB Antibodies) polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
hematopoietic lineage cell-specific protein
, hematopoietic cell-specific LYN substrate 1
, hematopoietic cell-specific Lyn substrate 1
, hematopoietic lineage cell-specific protein-like
, Hematopoietic lineage cell-specific protein
, uncharacterized protein LOC563056