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anti-Human IRS2 Antibodies:
anti-Rat (Rattus) IRS2 Antibodies:
anti-Mouse (Murine) IRS2 Antibodies:
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Human Polyclonal IRS2 Primary Antibody for IF (p), IHC (p) - ABIN725840
Ling, Xie, Li, Liu, Cao, Yang, Wang, Hu, Xu, Zheng: Donor Graft MicroRNAs: A Newly Identified Player in the Development of New-onset Diabetes After Liver Transplantation. in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016
Data show that JNK3 (show MAPK10 Antibodies) silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.
IRS-1 (show IRS1 Antibodies) and IRS-2 signaling interaction with the microtubule cytoskeleton and its response to AKT (show AKT1 Antibodies) determines the response to microtubule disruption in breast carcinoma cells
The study results were suggestive of a positive association between Gly972Arg of IRS1 (show IRS1 Antibodies) and PCOS in the south Indian population, while INS (show INS Antibodies), IRS2, PPAR-G (show ARF6 Antibodies) and CAPN10 (show CAPN10 Antibodies) failed to show any association with PCOS in our studied population.
We concluded that USP15 (show USP15 Antibodies) attenuates IGF-I (show IGF1 Antibodies) signaling by antagonizing Nedd4 (show NEDD4 Antibodies)-induced IRS-2 ubiquitination.
these data highlight two novel regulatory proteins that could be therapeutically manipulated to limit IL-4 (show IL4 Antibodies)-induced IRS-2 signaling and polarization of M2 macrophages in allergic inflammation.
Proteasomal inhibition prolonged IRS-2 tyrosine phosphorylation, increased ubiquitination of IRS-2, and enhanced M2 gene expression.
Findings suggest that insulin receptor substrate -1 (show IRS1 Antibodies) Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR Antibodies) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.
In the renal proximal tubule, insulin (show INS Antibodies) signaling via IRS1 (show IRS1 Antibodies) is inhibited, while insulin (show INS Antibodies) signaling via IRS2 is preserved. Insulin (show INS Antibodies) signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.
miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2.
High IRS2 expression is associated with myeloproliferative neoplasms.
FSH (show BRD2 Antibodies) decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization.
possible link between impaired insulin (show INS Antibodies) sensing by NGNs and hyperphagic obese phenotype in IRS2 knockout mice
Mutation of five "inhibitory" Ser (show SIGLEC1 Antibodies) phosphorylation sites on IRS2 in transgenic mice that overexpress, selectively in pancreatic beta-cells, either wild-type (WT) or a mutated IRS2 protein (IRS2(5A)) led to increased islets size, number, and mRNA levels of catalase (show CAT Antibodies) and superoxide dismutase (show SOD1 Antibodies), and decreased nitric oxide synthase (show NOS Antibodies) in 7- to 10-week-old IRS2(5A)-beta mice compared with IRS2(WT)-beta mice.
data identify SH2B1 (show SH2B1 Antibodies) as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 (show EIF4EBP2 Antibodies) as a major regulator of proliferation and survival of beta-cells.
Decreased miR (show MLXIP Antibodies)-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin (show INS Antibodies) signaling pathway in Irs-1 (show IRS1 Antibodies) deficient mice.
Acute knockdown of Insr (show INSR PLURAL_@2012@) or both Irs1 (show IRS1 PLURAL_@2012@) and Irs2 in adipocytes increased Adipoq (show ADIPOQ PLURAL_@2012@) mRNA expression but reduced adiponectin (show ADIPOQ PLURAL_@2012@) secretion.
Combination of DPP-4 (show DPP4 Antibodies) inhibitor and PPARgamma (show PPARG Antibodies) agonist exerts protective effects on pancreatic beta-cells in diabetic db/db (show LEPR Antibodies) mice through the augmentation of IRS-2 expression
discovered that Irs2 deficiency causes insulin (show INS Antibodies) resistance through up-regulation of the phosphatase and tensin homolog (PTEN (show PTEN Antibodies)). Importantly, suppressing PTEN (show PTEN Antibodies) in Irs2(-/-) podocytes rescued insulin (show INS Antibodies) sensitivity
A knockout mouse has confirmed the importance of IRS2 in the control of glucose homeostasis and especially in the survival and function of pancreatic beta-cells.
The data suggest that Irs2 deletion in endothelial cells leads to a decreased islet blood flow, which may cause impaired glucose-induced insulin (show INS Antibodies) secretion.
Results indicate that although IRS (show IARS Antibodies) isoforms (irs1 (show IRS1 Antibodies) and irs2) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.
The study identified the serine phosphorylation (p-Ser (show SIGLEC1 Antibodies)) sites induced by PKC-Beta (show PRKCB Antibodies) activation or AGT (show AGT Antibodies), which inhibits insulin (show INS Antibodies)-induced p-Tyr (show TYR Antibodies) sites on IRS2 and its signals in endothelial cells.
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
insulin receptor substrate 2
, tyrosine kinase substrate