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Browse our anti-IRS2 (IRS2) Antibodies

Full name:
anti-Insulin Receptor Substrate 2 Antibodies (IRS2)
On are 72 Insulin Receptor Substrate 2 (IRS2) Antibodies from 17 different suppliers available. Additionally we are shipping IRS2 Kits (26) and IRS2 Proteins (4) and many more products for this protein. A total of 106 IRS2 products are currently listed.
4PS, Irs-2, IRS2, si:dkeyp-24d6.1
list all antibodies Gene Name GeneID UniProt
IRS2 8660 Q9Y4H2
IRS2 29376  
IRS2 384783 P81122

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Most Popular Reactivities for anti-IRS2 (IRS2) Antibodies

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anti-Human IRS2 Antibodies:

anti-Rat (Rattus) IRS2 Antibodies:

anti-Mouse (Murine) IRS2 Antibodies:

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Top referenced anti-IRS2 Antibodies

  1. Human Polyclonal IRS2 Primary Antibody for EIA, IHC (p) - ABIN360098 : Hägg, Jernås, Wiklund, Thelle, Fagerberg, Eriksson, Hamsten, Olsson, Carlsson, Carlsson, Svensson: Expression profiling of macrophages from subjects with atherosclerosis to identify novel susceptibility genes. in International journal of molecular medicine 2008 (PubMed)
    Show all 3 references for ABIN360098

  2. Human Polyclonal IRS2 Primary Antibody for EIA - ABIN358522 : Sun, Wang, Zhang, Yenush, Myers, Glasheen, Lane, Pierce, White: Role of IRS-2 in insulin and cytokine signalling. in Nature 1995 (PubMed)
    Show all 3 references for ABIN358522

  3. Human Polyclonal IRS2 Primary Antibody for IF (p), IHC (p) - ABIN725840 : Ling, Xie, Li, Liu, Cao, Yang, Wang, Hu, Xu, Zheng: Donor Graft MicroRNAs: A Newly Identified Player in the Development of New-onset Diabetes After Liver Transplantation. in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016 (PubMed)

More Antibodies against IRS2 Interaction Partners

Zebrafish Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Data show that JNK3 (show MAPK10 Antibodies) silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.

Human Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Findings suggest that insulin receptor substrate -1 (show IRS1 Antibodies) Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR Antibodies) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  2. In the renal proximal tubule, insulin (show INS Antibodies) signaling via IRS1 (show IRS1 Antibodies) is inhibited, while insulin (show INS Antibodies) signaling via IRS2 is preserved. Insulin (show INS Antibodies) signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.

  3. miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2.

  4. High IRS2 expression is associated with myeloproliferative neoplasms.

  5. FSH (show BRD2 Antibodies) decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization.

  6. These data demonstrate for the first time that miR146a suppresses lung cancer progression by repressing IRS2 expression

  7. IRS (show IARS Antibodies)-specific gene signatures represent accurate surrogates of IGF activity and could predict response to anti-IGF therapy in breast cancer.

  8. Amplification of CUL4A (show CUL4A Antibodies), IRS2, and TFDP1 (show TFDP1 Antibodies) genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.

  9. These results indicate that miR (show MLXIP Antibodies)-106a* affects renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)) progression by targeting IRS-2 with suppression of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway in RCC (show XRCC1 Antibodies) cells

  10. meta-analysis of genetic association studies: Data suggest that the D allele of the G1057D SNP in IRS2 has a significant effect on reducing risk of type 2 diabetes mellitus; obesity is a modifier of this association. [META-ANALYSIS, REVIEW]

Mouse (Murine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Acute knockdown of Insr (show INSR Antibodies) or both Irs1 (show IRS1 Antibodies) and Irs2 in adipocytes increased Adipoq (show ADIPOQ Antibodies) mRNA expression but reduced adiponectin (show ADIPOQ Antibodies) secretion.

  2. Combination of DPP-4 (show DPP4 Antibodies) inhibitor and PPARgamma (show PPARG Antibodies) agonist exerts protective effects on pancreatic beta-cells in diabetic db/db (show LEPR Antibodies) mice through the augmentation of IRS-2 expression

  3. discovered that Irs2 deficiency causes insulin (show INS Antibodies) resistance through up-regulation of the phosphatase and tensin homolog (PTEN (show PTEN Antibodies)). Importantly, suppressing PTEN (show PTEN Antibodies) in Irs2(-/-) podocytes rescued insulin (show INS Antibodies) sensitivity

  4. A knockout mouse has confirmed the importance of IRS2 in the control of glucose homeostasis and especially in the survival and function of pancreatic beta-cells.

  5. The data suggest that Irs2 deletion in endothelial cells leads to a decreased islet blood flow, which may cause impaired glucose-induced insulin (show INS Antibodies) secretion.

  6. Results indicate that although IRS (show IARS Antibodies) isoforms (irs1 (show IRS1 Antibodies) and irs2) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

  7. Inhibition of Gsk-3beta (show GSK3b Antibodies) by Irs-2-dependent PI3K signaling promotes glucose uptake and aerobic glycolysis.

  8. Data (including data from knockout mice) suggest that Irs2 is not required for islet beta-cell proliferation (as seen with high-fat diet) but may be needed for beta-cell regeneration (as seen after partial pancreatectomy).

  9. IRS2 plays a critical role in testicular development, potentially by mediating IGF1 (show IGF1 Antibodies) signaling during embryonic and early postnatal development.

  10. Mice with combined cardiomyocyte-specific deletion of Irs1 & Irs2 (show IRS1 Antibodies) had unrestrained autophagy in cardiomyocytes, leading to myocyte loss, heart failure, premature death, apoptosis & mitochondrial dysfunction.

Cow (Bovine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. The study identified the serine phosphorylation (p-Ser (show SIGLEC1 Antibodies)) sites induced by PKC-Beta (show PRKCB Antibodies) activation or AGT (show AGT Antibodies), which inhibits insulin (show INS Antibodies)-induced p-Tyr (show TYR Antibodies) sites on IRS2 and its signals in endothelial cells.

IRS2 Antigen Profile

Antigen Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Alternative names and synonyms associated with IRS2

  • insulin receptor substrate 2 (IRS2) antibody
  • zgc:56306 (zgc:56306) antibody
  • insulin receptor substrate 2 (irs2) antibody
  • insulin receptor substrate 2 (Irs2) antibody
  • 4PS antibody
  • Irs-2 antibody
  • IRS2 antibody
  • si:dkeyp-24d6.1 antibody

Protein level used designations for IRS2

insulin receptor substrate 2 , tyrosine kinase substrate , 4PS

100146249 Equus caballus
393285 Danio rerio
452657 Pan troglodytes
572001 Danio rerio
8660 Homo sapiens
29376 Rattus norvegicus
384783 Mus musculus
100730395 Cavia porcellus
485548 Canis lupus familiaris
100300012 Bos taurus
428017 Gallus gallus
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