Browse our anti-IRS2 (IRS2) Antibodies

Full name:
anti-Insulin Receptor Substrate 2 Antibodies (IRS2)
On are 71 Insulin Receptor Substrate 2 (IRS2) Antibodies from 18 different suppliers available. Additionally we are shipping IRS2 Kits (27) and IRS2 Proteins (4) and many more products for this protein. A total of 106 IRS2 products are currently listed.
4PS, Irs-2, IRS2, si:dkeyp-24d6.1
list all antibodies Gene Name GeneID UniProt
IRS2 8660 Q9Y4H2
IRS2 29376  
IRS2 384783 P81122

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Top referenced anti-IRS2 Antibodies

  1. Human Polyclonal IRS2 Primary Antibody for EIA - ABIN358522 : Sun, Wang, Zhang, Yenush, Myers, Glasheen, Lane, Pierce, White: Role of IRS-2 in insulin and cytokine signalling. in Nature 1995 (PubMed)
    Show all 3 references for 358522

  2. Human Polyclonal IRS2 Primary Antibody for IF (p), IHC (p) - ABIN725840 : Ling, Xie, Li, Liu, Cao, Yang, Wang, Hu, Xu, Zheng: Donor Graft MicroRNAs: A Newly Identified Player in the Development of New-onset Diabetes After Liver Transplantation. in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016 (PubMed)

More Antibodies against IRS2 Interaction Partners

Zebrafish Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Data show that JNK3 (show MAPK10 Antibodies) silencing strongly decreases Insulin Receptor Substrate 2 (IRS2) protein expression.

Human Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. IRS-1 (show IRS1 Antibodies) and IRS-2 signaling interaction with the microtubule cytoskeleton and its response to AKT (show AKT1 Antibodies) determines the response to microtubule disruption in breast carcinoma cells

  2. The study results were suggestive of a positive association between Gly972Arg of IRS1 (show IRS1 Antibodies) and PCOS in the south Indian population, while INS (show INS Antibodies), IRS2, PPAR-G (show ARF6 Antibodies) and CAPN10 (show CAPN10 Antibodies) failed to show any association with PCOS in our studied population.

  3. We concluded that USP15 (show USP15 Antibodies) attenuates IGF-I (show IGF1 Antibodies) signaling by antagonizing Nedd4 (show NEDD4 Antibodies)-induced IRS-2 ubiquitination.

  4. these data highlight two novel regulatory proteins that could be therapeutically manipulated to limit IL-4 (show IL4 Antibodies)-induced IRS-2 signaling and polarization of M2 macrophages in allergic inflammation.

  5. Proteasomal inhibition prolonged IRS-2 tyrosine phosphorylation, increased ubiquitination of IRS-2, and enhanced M2 gene expression.

  6. Findings suggest that insulin receptor substrate -1 (show IRS1 Antibodies) Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR Antibodies) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  7. In the renal proximal tubule, insulin (show INS Antibodies) signaling via IRS1 (show IRS1 Antibodies) is inhibited, while insulin (show INS Antibodies) signaling via IRS2 is preserved. Insulin (show INS Antibodies) signaling via IRS2 continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.

  8. miRNA-146a may function as a useful clinical tool in the treatment and diagnosis of ESCC, and its overexpression suppressed cell growth through inhibition of IRS2.

  9. High IRS2 expression is associated with myeloproliferative neoplasms.

  10. FSH (show BRD2 Antibodies) decreases IRS-2 mRNA degradation indicating post-transcriptional stabilization.

Mouse (Murine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. Mutation of five "inhibitory" Ser (show SIGLEC1 Antibodies) phosphorylation sites on IRS2 in transgenic mice that overexpress, selectively in pancreatic beta-cells, either wild-type (WT) or a mutated IRS2 protein (IRS2(5A)) led to increased islets size, number, and mRNA levels of catalase (show CAT Antibodies) and superoxide dismutase (show SOD1 Antibodies), and decreased nitric oxide synthase (show NOS Antibodies) in 7- to 10-week-old IRS2(5A)-beta mice compared with IRS2(WT)-beta mice.

  2. data identify SH2B1 (show SH2B1 Antibodies) as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 (show EIF4EBP2 Antibodies) as a major regulator of proliferation and survival of beta-cells.

  3. Decreased miR (show MLXIP Antibodies)-33 levels can up-regulate IRS-2 expression, which appears to compensate for the defects of the insulin (show INS Antibodies) signaling pathway in Irs-1 (show IRS1 Antibodies) deficient mice.

  4. Acute knockdown of Insr (show INSR Antibodies) or both Irs1 (show IRS1 Antibodies) and Irs2 in adipocytes increased Adipoq (show ADIPOQ Antibodies) mRNA expression but reduced adiponectin (show ADIPOQ Antibodies) secretion.

  5. Combination of DPP-4 (show DPP4 Antibodies) inhibitor and PPARgamma (show PPARG Antibodies) agonist exerts protective effects on pancreatic beta-cells in diabetic db/db (show LEPR Antibodies) mice through the augmentation of IRS-2 expression

  6. discovered that Irs2 deficiency causes insulin (show INS Antibodies) resistance through up-regulation of the phosphatase and tensin homolog (PTEN (show PTEN Antibodies)). Importantly, suppressing PTEN (show PTEN Antibodies) in Irs2(-/-) podocytes rescued insulin (show INS Antibodies) sensitivity

  7. A knockout mouse has confirmed the importance of IRS2 in the control of glucose homeostasis and especially in the survival and function of pancreatic beta-cells.

  8. The data suggest that Irs2 deletion in endothelial cells leads to a decreased islet blood flow, which may cause impaired glucose-induced insulin (show INS Antibodies) secretion.

  9. Results indicate that although IRS (show IARS Antibodies) isoforms (irs1 (show IRS1 Antibodies) and irs2) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

  10. Inhibition of Gsk-3beta (show GSK3b Antibodies) by Irs-2-dependent PI3K signaling promotes glucose uptake and aerobic glycolysis.

Cow (Bovine) Insulin Receptor Substrate 2 (IRS2) interaction partners

  1. The study identified the serine phosphorylation (p-Ser (show SIGLEC1 Antibodies)) sites induced by PKC-Beta (show PRKCB Antibodies) activation or AGT (show AGT Antibodies), which inhibits insulin (show INS Antibodies)-induced p-Tyr (show TYR Antibodies) sites on IRS2 and its signals in endothelial cells.

IRS2 Antigen Profile

Antigen Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Alternative names and synonyms associated with IRS2

  • insulin receptor substrate 2 (IRS2) antibody
  • zgc:56306 (zgc:56306) antibody
  • insulin receptor substrate 2 (irs2) antibody
  • insulin receptor substrate 2 (Irs2) antibody
  • 4PS antibody
  • Irs-2 antibody
  • IRS2 antibody
  • si:dkeyp-24d6.1 antibody

Protein level used designations for IRS2

insulin receptor substrate 2 , tyrosine kinase substrate , 4PS

100146249 Equus caballus
393285 Danio rerio
452657 Pan troglodytes
572001 Danio rerio
8660 Homo sapiens
29376 Rattus norvegicus
384783 Mus musculus
100730395 Cavia porcellus
485548 Canis lupus familiaris
100300012 Bos taurus
428017 Gallus gallus
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