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InsP3 dependent sarcoplasmic reticulum-Ca2 (show CA2 ELISA Kits)+ flux constitute the main mechanism of functional crosstalk between InsP3R2 and RyR2 (show RYR2 ELISA Kits) resulting in more Ca2 (show CA2 ELISA Kits)+ sensitized RyRs to trigger subsequent Ca2 (show CA2 ELISA Kits)+-induced Ca2 (show CA2 ELISA Kits)+ release activation.
the absence of IP3R2 led to increased innate immunity, which may contribute to the decreased survival of the SOD1(G93A) mice.our data indicate that IP3R2 protects against the negative effects of inflammation, suggesting that the increase in IP3R2 expression in ALS patients is a protective response.
Using inositol 1,4,5-trisphosphate receptor type 2 knockout (Itpr2(-/-)) mice to specifically disturb somatic Ca(2 (show CA2 ELISA Kits)+) signaling in astrocytes, the authors showed that developmental elimination of the ventral posteromedial nucleus relay synapse was impaired.
IP3R2 KO mice had smaller infarction than WT mice in acute and chronic phases of ischemia
Akt2 (show AKT2 ELISA Kits) upregulates dendritic cell migration at least in part by ETS1 (show ETS1 ELISA Kits)-dependent stimulation of IP3R2 transcription.
Disrupting IP3R (show ITPR1 ELISA Kits)/Bcl-2 (show BCL2 ELISA Kits) interaction therefore leads in those cells to increased Ca(2 (show CA2 ELISA Kits)) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism.
reduced InsP3R (show ITPR1 ELISA Kits)-II expression is not sufficient to account for any disruptions in metabolic homeostasis that are observed in mouse models of obesity
ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc (show NFATC1 ELISA Kits) signaling pathways.
This study demonistrated that hippocampal slices from inositol triphosphate receptor type 2 (IP3R2) knock-out mice which abolished the astrocytic Ca(2 (show CA2 ELISA Kits)+) activity.
IP3R (show ITPR1 ELISA Kits)-deficient acinar cells accumulate zymogen granules, but the mice do not succumb to pancreatic damage or worse pancreatitis outcomes.
Studies indicate that the ryanodine receptors (RyRs: RyR1 (show RYR1 ELISA Kits), RyR2 (show RYR2 ELISA Kits), RyR3 (show RYR3 ELISA Kits)) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1 (show ITPR1 ELISA Kits), IP3R2, IP3R3 (show ITPR3 ELISA Kits)) are the major Ca(2 (show CA2 ELISA Kits)+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).
Data suggest miR (show MLXIP ELISA Kits)-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF (show MAF ELISA Kits) and ITPR2.
results show a functional role of calcium release by the ITPR2 channel and its subsequent accumulation in the mitochondria
High expression of inositol 1,4,5-trisphosphate receptor, type 2 is associated with acute myeloid leukemia (show BCL11A ELISA Kits).
A genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese.
Loss of InsP3R2-mediated calcium release causes isolated anhidrosis in humans.
The Galphaq (show GNAQ ELISA Kits)-protein/coupled receptor/IP3R (show ITPR1 ELISA Kits) axis modulates the electromechanical properties of the human myocardium and its propensity to develop arrhythmias.
Studies indicate that three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1 (show ITPR1 ELISA Kits), -2, and -3) are assembled to form homo- and heterotetrameric channels that mediate Ca(2 (show CA2 ELISA Kits)+) release from intracellular stores.
receptor for inositol 1,4,5-triphosphate\; involved in regulating intracellular Ca(2+) concentration
inositol 1,4,5-trisphosphate receptor, type 2
, inositol 1,4,5-triphosphate receptor, type 2
, IP3 receptor
, IP3R 2
, inositol 1,4,5-triphosphate receptor 5
, inositol 1,4,5-trisphosphate receptor type 2
, inositol 1,4,5-trisphosphate type V receptor
, inositol trisphosphate receptor type 2
, type 2 InsP3 receptor
, type 2 inositol 1,4,5-trisphosphate receptor
, inositol 1,4,5-triphosphate receptor 2
, inositol triphosphate receptor type 2