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LAT1 (show LAT ELISA Kits) and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.
The detergent-induced stabilization of the purified human 4F2hc (show SLC3A2 ELISA Kits)-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution
The AML1 (show RUNX1 ELISA Kits)/ETO (show RUNX1T1 ELISA Kits) target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy.
NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK (show EPHB2 ELISA Kits).
LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2 (show GRB2 ELISA Kits)-ERK (show EPHB2 ELISA Kits)-cPLA2 (show PLA2G4A ELISA Kits) signalling cascade at early stages of H. pylori infection.
data show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells (show LAT ELISA Kits))in non-T cells [non-T cell activation linker]
LAB links BCR (show BCR ELISA Kits) engagement to downstream signaling pathways.
LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr (show TYR ELISA Kits)(136), Tyr (show TYR ELISA Kits)(193), and Tyr (show TYR ELISA Kits)(233). Mutation of these three tyrosines abolished Grb2 (show GRB2 ELISA Kits) binding and LAB function
LAB resembled a LAT (show ORC3 ELISA Kits) molecule unable to bind phospholipase C (show PLC ELISA Kits)-gamma1.
NTAL is a negative regulator of FcepsilonRI (show FCER1A ELISA Kits) activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations.
Cerebral cortex hyperthyroidism of newborn mct8 (show MCT8 ELISA Kits)-deficient mice transiently suppressed by lat2 (show SLC7A8 ELISA Kits) inactivation.
Our data define a novel link between LAB and beta-catenin (show CTNNB1 ELISA Kits) nuclear accumulation in dendritic cells that facilitates IFN-gamma (show IFNG ELISA Kits) responses during anti-fungal immunity
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
Dihydrotestosterone treatment increased the expression of LAT2 (show SLC7A8 ELISA Kits).
The expression of Mct8 (show MCT8 ELISA Kits) and L-type amino acid transporters Lat2 (show SLC7A8 ELISA Kits) and Lat1 (show SLC7A5 ELISA Kits) are determined in brain neurons during development.
a crucial role of NTAL in signaling, via RhoA (show RHOA ELISA Kits), to mast cell cytoskeleton.
While SLP-76 (show LCP2 ELISA Kits) and LAT1 (show SLC7A5 ELISA Kits) depend on each other for many of their functions, LAT2 (show SLC7A8 ELISA Kits)/SLP-76 (show LCP2 ELISA Kits) interactions and SLP-76 (show LCP2 ELISA Kits)-independent LAT1 (show SLC7A5 ELISA Kits) functions also mediate a positive signaling pathway downstream of FcepsilonRI (show FCER1A ELISA Kits) in mast cells.
LAB is a critical, LAT (show LAT ELISA Kits)-independent regulator of TREM-2 (show TREM2 ELISA Kits) signaling and macrophage development capable of controlling subsequent inflammatory responses
NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells.
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.
Williams-Beuren syndrome chromosomal region 15 protein
, Williams-Beuren syndrome chromosomal region 5 protein
, linker for activation of B-cells
, linker for activation of T cells, transmembrane adaptor 2
, linker for activation of T-cells family member 2
, membrane-associated adapter molecule
, non-T-cell activation linker
, Williams-Beuren syndrome chromosome region 5 homolog
, non-T cell activation linker
, linker for activation of T cells family, member 2
, L-type amino acid transporter subunit
, Williams-Beuren syndrome chromosome region 5-like protein
, Williams-Beuren syndrome chromosome region 15 homolog
, williams-Beuren syndrome chromosomal region 15 protein homolog