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Browse our anti-LCP2 (LCP2) Antibodies

Full name:
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) Antibodies (LCP2)
On www.antibodies-online.com are 132 Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) Antibodies from 22 different suppliers available. Additionally we are shipping LCP2 Proteins (8) and LCP2 Kits (4) and many more products for this protein. A total of 154 LCP2 products are currently listed.
Synonyms:
AI323664, BB161688, SLP-76, Slp76, twm
list all antibodies Gene Name GeneID UniProt
LCP2 16822 Q60787
LCP2 155918  
LCP2 3937 Q13094

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Most Popular Reactivities for anti-LCP2 (LCP2) Antibodies

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anti-Mouse (Murine) LCP2 Antibodies:

anti-Rat (Rattus) LCP2 Antibodies:

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Top referenced anti-LCP2 Antibodies

  1. Human Monoclonal LCP2 Primary Antibody for IF, IP - ABIN968146 : Harder, Kuhn: Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies. in The Journal of cell biology 2000 (PubMed)
    Show all 5 references for ABIN968146

  2. Human Polyclonal LCP2 Primary Antibody for IHC (p), WB - ABIN94501 : Bogin, Ainey, Beach, Yablonski: SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 5 references for ABIN94501

  3. Human Monoclonal LCP2 Primary Antibody for IHC (p), WB - ABIN94466 : Silverman, Shoag, Wu, Koretzky: Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. in Molecular and cellular biology 2006 (PubMed)
    Show all 4 references for ABIN94466

  4. Human Monoclonal LCP2 Primary Antibody for WB - ABIN967606 : Fang, Motto, Ross, Koretzky: Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. in Journal of immunology (Baltimore, Md. : 1950) 1996 (PubMed)
    Show all 3 references for ABIN967606

  5. Human Monoclonal LCP2 Primary Antibody for WB - ABIN967597 : Janssen, Zhang: Adaptor proteins in lymphocyte activation. in Current opinion in immunology 2003 (PubMed)
    Show all 3 references for ABIN967597

  6. Human Monoclonal LCP2 Primary Antibody for ICS - ABIN1177173 : Wu, Koretzky: The SLP-76 family of adapter proteins. in Seminars in immunology 2004 (PubMed)
    Show all 2 references for ABIN1177173

  7. Human Monoclonal LCP2 Primary Antibody for IP, WB - ABIN264523 : Jackman, Motto, Sun, Tanemoto, Turck, Peltz, Koretzky, Findell: Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. in The Journal of biological chemistry 1995 (PubMed)
    Show all 2 references for ABIN264523

  8. Human Polyclonal LCP2 Primary Antibody for IHC, ELISA - ABIN1532089 : Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012 (PubMed)

More Antibodies against LCP2 Interaction Partners

Mouse (Murine) Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (show RANGAP1 Antibodies) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) nuclear entry in T cells

  2. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice

  3. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.

  4. this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 Antibodies)-Lat (show LAT Antibodies)-SLP-76 network and thus should provide cues for future functional experiments.

  5. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (show PRAM1 Antibodies)/SKAP-HOM (show SKAP2 Antibodies) and SLP-76/Vav (show VAV1 Antibodies)/PLCgamma2 (show PLCG2 Antibodies) signaling hubs may be critical for Yersinia survival.

  6. analysis of a costimulatory mechanism by which CXCL12 (show CXCL12 Antibodies) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  7. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Antibodies) and the IL-3 (show Il3 Antibodies) receptor.

  8. These findings reveal a novel role for SLP-76 in CXCR4 (show CXCR4 Antibodies)-mediated T lymphocyte trafficking.

  9. a novel regulation mechanism of SLP-76 by ubiquitination and proteasomal degradation of activated SLP-76, which is mediated by Ser-376 phosphorylation, leading to down-regulation of TCR signaling.

  10. Loss of SLP-76 has no effect on persistence of the antigen-specific CD4 (show CD4 Antibodies)+ memory pool, suggesting that homeostatic turnover is not required for persistence of this population.

Human Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  2. TSAD (show SH2D2A Antibodies) binds to and co-localizes with Nck (show NCK1 Antibodies). Expression of TSAD (show SH2D2A Antibodies) increases both Nck (show NCK1 Antibodies)-Lck (show LCK Antibodies) and Nck (show NCK1 Antibodies)-SLP-76 interaction in T cells.

  3. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (show RANGAP1 Antibodies) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) nuclear entry in T cells

  4. SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling

  5. analysis of a costimulatory mechanism by which CXCL12 (show CXCL12 Antibodies) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  6. Multipoint binding of SLP-76 to ADAP (show FYB Antibodies) facilitates the assembly of SLP-76 microclusters.

  7. Data indicate a role for the SAM (show TTN Antibodies) domain in mediating SLP-76 self-association for T-cell function.

  8. Data indicate that the intracellular signaling of ITK (show ITK Antibodies)-SYK (show SYK Antibodies) requires both SLP-76 and the adapter function of SYK (show SYK Antibodies)/ZAP-70 (show ZAP70 Antibodies) kinases.

  9. Unique modes of regulation of positive and negative feedback pathways in T cells by SLP-76.

  10. These findings reveal a novel role for SLP-76 in CXCR4 (show CXCR4 Antibodies)-mediated T lymphocyte trafficking.

LCP2 Antigen Profile

Antigen Summary

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Alternative names and synonyms associated with LCP2

  • lymphocyte cytosolic protein 2 (Lcp2) antibody
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2) antibody
  • AI323664 antibody
  • BB161688 antibody
  • SLP-76 antibody
  • Slp76 antibody
  • twm antibody

Protein level used designations for LCP2

SH2 domain-containing leukocyte protein of 76 kDa , SLP-76 tyrosine phosphoprotein , lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) , 76 kDa tyrosine phosphoprotein , SH2 domain-containing leukocyte protein of 76kD , lymphocyte cytosolic protein 2 , tyrosine phosphoprotein slp-76

GENE ID SPECIES
16822 Mus musculus
155918 Rattus norvegicus
3937 Homo sapiens
100511843 Sus scrofa
489126 Canis lupus familiaris
513244 Bos taurus
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