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A novel pancancer mechanism of Lyn-dependent control of epithelial-mesenchymal transition and role of this kinase in tumor progression.
Authors demonstrate that LYN kinase is essential for CLL progression. Lyn deficiency results in a significantly reduced CLL burden in vivo.
Our studies indicate not only a concept of mucus hypersecretion in asthma that involves Lyn kinase but also an important therapeutic candidate for asthma.
LPS (show IRF6 ELISA Kits) tolerance interferes with TLR4 (show TLR4 ELISA Kits) signaling by inhibiting Lyn and c-Src (show SRC ELISA Kits) phosphorylation and their recruitment to TLR4 (show TLR4 ELISA Kits), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 ELISA Kits), PTPN22 (show PTPN22 ELISA Kits), PTP1B (show PTPN1 ELISA Kits) and MKP1 (show DUSP1 ELISA Kits).
SYK (show SYK ELISA Kits), LYN and PTPN6 (show PTPN6 ELISA Kits) were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Our data suggests that nuclear Lyn is a potential therapeutic target for clear cell renal cell carcinoma and dasatinib affects cellular functions associated with cancer progression via a Src kinase (show CSK ELISA Kits) independent mechanism.
Authors discovered in this study that LYN was a critical gene. It was found to be the key nodule of several significant biological networks.
Inhibition of Lyn activity using dasatinib in mantle cell lymphoma overcomes bortezomib resistance.
positively regulates NF-kappaB (show NFKB1 ELISA Kits) transactivation through the phosphorylation of the p110 subunit of PI 3 (show PI3 ELISA Kits)-kinase
This study showed an interdependence between ROS (show ROS1 ELISA Kits) generation and lipid rafts and Lyn relocation leading the cells to undergo the successive acrosome reaction.
these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88 (show MYD88 ELISA Kits)-IRF5 (show IRF5 ELISA Kits) pathway and illustrate the importance of fine-tuning IRF5 (show IRF5 ELISA Kits) activity for the maintenance of immune homeostasis
These findings reveal that the function and regulation of Lyn during B1 cell B cell receptor signaling is distinct from other B cell subsets.
A mutation in LYN, an inhibitory protein tyrosine kinase (show YES1 ELISA Kits) that is implicated in systemic autoimmunity, combines with an Aire (show AIRE ELISA Kits) mutation to provoke organ-specific autoimmunity.
the Hck (show HCK ELISA Kits), Fgr (show FGR ELISA Kits) and Lyn kinases are also necessary for amastigote uptake by macrophages. Src (show SRC ELISA Kits)-mediated Arg activation is required for efficient uptake.
the Lyn mutation in NOD neutrophils is likely responsible for dysregulation of neutrophil adhesion and directed migration.
Oxidized LDL-bound CD36 (show CD36 ELISA Kits) recruits an Na/K-ATPase (show ATP1A1 ELISA Kits)-Lyn complex in macrophages that promotes atherosclerosis.
Lyn kinase modulates inhibitory signaling to suppress endotoxin-induced lung inflammation.
A complex functional interplay between FcgammaRIIa, Lyn, and alphaIIbbeta3 in immune complex-induced platelet activation.
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
tyrosine-protein kinase Lyn
, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein
, lyn protein tyrosine kinase
, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, Tyrosine-protein kinase Lyn
, lck/Yes-related novel protein tyrosine kinase
, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
, lyn protein non-receptor kinase
, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog