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in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
study found a difference in the frequencies of genotypes of FcvarepsilonRIbeta subunit int 2 (show FGF3 Proteins) in allergic rhinitis patients and controls. The FcvarepsilonRIbeta subunit int 2 (show FGF3 Proteins) gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort
MS4A2 (show MS4A1 Proteins) was differentially expressed between Fibromyalgia patients and healthy controls.
FcepsilonRIbeta -109C/T and IFN-gamma (show IFNG Proteins) 874T/A polymorphisms may be influencing factors for asthma in the Asian population
The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses.
Data indicated that the MS4A2 (show MS4A1 Proteins) gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians.
Cytoplasmic FcepsilonRIbeta, which is not co-localized with FcepsilonRIalpha, may function as a negative regulator, as it can capture important signalling molecules such as Lyn (show LYN Proteins).
t-FcepsilonRIbeta mediates Ca2 (show CA2 Proteins)+ -dependent microtubule formation, which promotes degranulation and cytokine release.
The interaction between Lyn (show LYN Proteins) and FcepsilonRIbeta is indispensable for FcepsilonRI (show FCER1G Proteins)-mediated human mast cell activation.
Demethylation of specific regulatory elements within the FCER1G (show FCER1G Proteins) locus contributes to FcepsilonRI (show FCER1G Proteins) overexpression on monocytes from patients with atopic dermatitis.
Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor beta chain polymorphic proteins has been presented.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (show FCER1A Proteins), tetraspanin CD9 (show CD9 Proteins), transmembrane adaptor proteins NTAL (show LAT2 Proteins) and LAT (show LAT Proteins), and cytoskeleton-regulatory proteins of the ERM (show ETV5 Proteins) family
Findings indicate that SLP-76 (show LCP2 Proteins) is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Proteins) and the IL-3 (show IL-3 Proteins) receptor.
FcRbeta is a critical element in mast cell synergistic degranulation response through FcepsilonRI (show FCER1A Proteins) & adenosine receptors. PI3K-signaling through FcRbeta-ITAM is a crucial participant in augmentation of FcepsilonRI (show FCER1A Proteins)-mediated degranulation by adenosine.
inhibition of FcepsilonRI (show FCER1A Proteins)-dependent mast cell activation can suppress allergic contact dermatitis
Gene expression profiling after stimulation via high-affinity Fcepsilon receptor I (FcepsilonRI (show FCER1A Proteins)), showed the transcriptional levels of several CC chemokines were markedly increased.
FcepsilonRIbeta functions to both selectively amplify (degranulation and leukotriene secretion) and dampen (lymphokine (show IL2 Proteins)) mast cell effector responses
IgE receptors are expressed on sensory neurons in mice. Immunostaining revealed that the high affinity IgE receptor FcepsilonRI (show FCER1A Proteins) was expressed in cultured dorsal root ganglion cells.
FcepsilonRI (show FCER1A Proteins) beta-chain regulates calcium uptake in mast cells via the immunoreceptor tyrosine-based activation motif.
IgE signaling suppresses FcepsilonRIbeta expression.
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Fc fragment of IgE, high affinity I, receptor for; beta polypeptide
, High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)
, high affinity IgE receptor beta subunit
, high affinity immunoglobulin epsilon receptor subunit beta
, igE Fc receptor subunit beta
, immunoglobulin E receptor, high affinity, beta polypeptide
, Fc receptor, IgE, high affinity I, beta polypeptide
, fc epsilon receptor I beta-chain
, membrane-spanning 4-domains, subfamily A, member 1
, IgE Fc receptor subunit beta
, Membrane-spanning 4-domains subfamily A member 1
, Membrane-spanning 4-domains, subfamily A, member 1
, beta polypeptide)
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)