Browse our anti-PDGFRA (PDGFRA) Antibodies

Full name:
anti-Platelet-Derived Growth Factor Receptor, alpha Polypeptide Antibodies (PDGFRA)
On www.antibodies-online.com are 540 Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies from 32 different suppliers available. Additionally we are shipping PDGFRA Kits (56) and PDGFRA Proteins (32) and many more products for this protein. A total of 657 PDGFRA products are currently listed.
Synonyms:
AI115593, APDGFR, CD140A, PDGFACE, PDGFR, PDGFR-2, PDGFR-A, PDGFR2, RHEPDGFRA
list all antibodies Gene Name GeneID UniProt
PDGFRA 18595 P26618
PDGFRA 25267 P20786
PDGFRA 5156 P16234

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Top referenced anti-PDGFRA Antibodies

  1. Human Polyclonal PDGFRA Primary Antibody for IHC (p), WB - ABIN392024 : Wilczynski, Chen, Chen, Howell, Shively, Alberts: Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. in Human pathology 2005 (PubMed)
    Show all 5 references for 392024

  2. Human Polyclonal PDGFRA Primary Antibody for IHC (p), WB - ABIN392029 : Hiwatari, Taki, Tsuchida, Hanada, Hongo, Sako, Hayashi: Novel missense mutations in the tyrosine kinase domain of the platelet-derived growth factor receptor alpha(PDGFRA) gene in childhood acute myeloid leukemia with t(8;21)(q22;q22) or inv(16)(p13q22). in Leukemia 2005 (PubMed)
    Show all 5 references for 392029

  3. Human Polyclonal PDGFRA Primary Antibody for EIA, IHC (p) - ABIN359912 : Chen, Wang, Huang, Liu: [Experimental study on effects of shengmai injection: enhancing 5-FU anti-tumor efficacy and reducing its toxicity]. in Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 2005 (PubMed)
    Show all 5 references for 359912

  4. Human Polyclonal PDGFRA Primary Antibody for IHC (p), WB - ABIN392025 : Subramanian, West, Corless, Ou, Rubin, Chu, Leung, Yuen, Zhu, Hernandez-Boussard, Montgomery, Nielsen, Patel, Goldblum, Heinrich, Fletcher, van de Rijn: Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. in Oncogene 2004 (PubMed)
    Show all 5 references for 392025

  5. Human Polyclonal PDGFRA Primary Antibody for EIA, IF - ABIN359914 : Debiec-Rychter, Cools, Dumez, Sciot, Stul, Mentens, Vranckx, Wasag, Prenen, Roesel, Hagemeijer, Van Oosterom, Marynen: Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. in Gastroenterology 2005 (PubMed)
    Show all 5 references for 359914

  6. Human Polyclonal PDGFRA Primary Antibody for EIA, IHC (p) - ABIN359906 : Cools, DeAngelo, Gotlib, Stover, Legare, Cortes, Kutok, Clark, Galinsky, Griffin, Cross, Tefferi, Malone, Alam, Schrier, Schmid, Rose, Vandenberghe, Verhoef, Boogaerts, Wlodarska, Kantarjian, Marynen et al.: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. ... in The New England journal of medicine 2003 (PubMed)
    Show all 5 references for 359906

  7. Human Polyclonal PDGFRA Primary Antibody for IHC (p), WB - ABIN392027 : Sakurai, Hasegawa, Sakuma, Takazawa, Motegi, Nakajima, Saito, Fukayama, Shimoda: Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene. in Human pathology 2004 (PubMed)
    Show all 5 references for 392027

  8. Human Polyclonal PDGFRA Primary Antibody for FACS, IHC (p) - ABIN392022 : Andrae, Molander, Smits, Funa, Nistér: Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells. in Biochemical and biophysical research communications 2002 (PubMed)

More Antibodies against PDGFRA Interaction Partners

Mouse (Murine) Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) interaction partners

  1. PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb (show PDGFRB Antibodies) in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.

  2. The results from this study indicate that PDGF (show PDGFA Antibodies) signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.

  3. transient middle cerebral-arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb (show PDGFRB Antibodies)-gene inactivation, including N-PRbeta-KO mice where the Pdgfrb (show PDGFRB Antibodies)-gene was mostly inactivated in the brain except that in vascular pericytes

  4. PDGFR alpha has an important role in cranial neural crest cell mitosis within the mandibular processes

  5. PDGF (show PDGFA Antibodies) signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.

  6. PDGFRalpha has a role in demarcating the cardiogenic clonogenic Sca1 (show ATXN1 Antibodies)+ stem/progenitor cell in adult murine myocardium

  7. In KIT-mutant GIST, inhibition of PDGFRA disrupts a KIT-ERK (show EPHB2 Antibodies)-ETV1 (show ETV1 Antibodies)-KIT signaling loop by inhibiting ERK (show EPHB2 Antibodies) activation.

  8. Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase (show YES1 Antibodies).

  9. Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF (show PDGFA Antibodies)/PDGFR (show PDGFRB Antibodies) signaling activation.

  10. Data indicate that PDGF (show PDGFA Antibodies)-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2 (show BMP2 Antibodies))-smad (show SMAD1 Antibodies) proteins smad1 (show SMAD1 Antibodies)/5/8 activation requires lysosome-mediated degradation of PDGF (show PDGFA Antibodies) alpha Receptor (PDGFRalpha).

Human Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) interaction partners

  1. PDGFRa amplification in multiple skin lesions of undifferentiated pleomorphic sarcoma

  2. PDGFRA mutations were associated with gastrointestinal stromal tumors.

  3. The PDGFRA kinase domain structure we report in this study has potential to facilitate development of new agents which can inhibit this kinase, including both its activating and drug-resistant mutations.

  4. BRAF (show BRAF Antibodies) mutations are rare events in KIT/PDGFRA wild-type gastrointestinal stromal tumors.

  5. There are two platelet-derived growth factor receptor (PDGFR (show PDGFRB Antibodies)) genes (PDGFRA and PDGFRB (show PDGFRB Antibodies)), and they reside on chromosome 4 and 5.

  6. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

  7. Synchronous T lymphoblastic lymphoma and myeloid neoplasm with PDGFRA rearrangement.

  8. Stromal expression of PDGFRA increased with increasing histologic grade of breast phyllodes tumor. PDGFR (show PDGFRB Antibodies) stromal positivity was associated with shorter overall survival.

  9. genome analysis of wild-type gastrointestinal stromal tumors for mutations should include the BRAF (show BRAF Antibodies) gene in patients with KIT and PDGFRA wild-type gastrointestinal stromal tumors

  10. We demonstrate in cell lines, SCID (show PRKDC Antibodies) xenografts and human tumor specimens that PDGFRalpha promotes dedifferentiation in PTC (show F9 Antibodies) by decreasing TTF1 (show NKX2-1 Antibodies) expression in the nucleus, which decreases iodide transport and thyroglobulin (show TG Antibodies) production in thyroid follicular cells.

PDGFRA Antigen Profile

Antigen Summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

Alternative names and synonyms associated with PDGFRA

  • platelet-derived growth factor receptor, alpha polypeptide (PDGFRA) antibody
  • platelet-derived growth factor receptor, alpha polypeptide (LOC100218386) antibody
  • platelet derived growth factor receptor, alpha polypeptide (Pdgfra) antibody
  • platelet derived growth factor receptor, alpha polypeptide (pdgfra) antibody
  • platelet-derived growth factor receptor alpha (LOC100343006) antibody
  • AI115593 antibody
  • APDGFR antibody
  • CD140A antibody
  • PDGFACE antibody
  • PDGFR antibody
  • PDGFR-2 antibody
  • PDGFR-A antibody
  • PDGFR2 antibody
  • RHEPDGFRA antibody

Protein level used designations for PDGFRA

platelet-derived growth factor receptor, alpha polypeptide , alpha-type platelet-derived growth factor receptor-like , Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha) , CD140 antigen-like family member A , PDGF alpha chain , PDGF-R-alpha , PDGFR-alpha , alpha-type platelet-derived growth factor receptor , platelet-derived growth factor alpha receptor , platelet-derived growth factor receptor alpha , alpha platelet-derived growth factor receptor , CD140a antigen , PDGFRA/BCR fusion , platelet-derived growth factor receptor 2 , rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein , tyrosine kinase PDGFR

GENE ID SPECIES
100059815 Equus caballus
100218386 Taeniopygia guttata
100412331 Callithrix jacchus
100431735 Pongo abelii
100464991 Ailuropoda melanoleuca
18595 Mus musculus
25267 Rattus norvegicus
380245 Xenopus laevis
100343006 Oryctolagus cuniculus
5156 Homo sapiens
442860 Canis lupus familiaris
407607 Sus scrofa
282301 Bos taurus
395509 Gallus gallus
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