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NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65.
Syk is a key regulator of Hoxa9 (show HOXA9 ELISA Kits)/Meis1 (show MEIS1 ELISA Kits)-driven acute myeloid leukemia (show BCL11A ELISA Kits).
Data show that spleen tyrosine kinase (SYK) and proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (AKT1 (show AKT1 ELISA Kits)) proteins were increased in the cytoplasm of the cells forming Mallory-Denk bodies.
B cell receptor signaling component, SYK, caused PAX5 (show PAX5 ELISA Kits) tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (show PRDM1 ELISA Kits) promoter by PAX5 (show PAX5 ELISA Kits) was attenuated by this phosphorylation.
Pharmacological inhibitors of SYK activity significantly reduced the engulfment of oxLDL microbeads in the presence of serum factors, but had little effect on IgG phagocytosis.
our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK (show IRAK1 ELISA Kits) and Syk, linked to the activation of NF-kappaB (show NFKB1 ELISA Kits) and AP-1 (show FOSB ELISA Kits).
a potential link between the upregulation of Syk and VEGF-C (show VEGFC ELISA Kits) expression and lung adenocarcinoma.
The lack of Syk mRNA expression in lung cancer play an important role in angiogenesis.
Overall novel mutations in SYK gene and in silico analysis revealed that these mutations are crucial and might be responsible for altered expression of SYK.
this study shows that SYK increased MUC5AC expression via ERK2 (show MAPK1 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) signaling pathways in airway epithelial cells
Pharmacological Syk inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and to limit infarct progression in acute stroke.
Studies indicate that SHP1 (show PTPN6 ELISA Kits) and SYK crosstalk as a critical regulator of MyD88 (show MYD88 ELISA Kits) post-translational modifications and IL-1 (show IL1A ELISA Kits)-driven inflammation.
dephosphorylation of Tyr (show TYR ELISA Kits)(P)(346) may be considered an important "checkpoint" in the regulation of Syk activation process. Putative biological functions of TULA-2 (show STS1 ELISA Kits)-mediated dephosphorylation of Tyr (show TYR ELISA Kits)(P)(346) may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation.
These studies define a pathologic role for myeloid Syk signaling in renal ischemia/reperfusion injury
Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (show SRC ELISA Kits)/Syk/NF-kappaB (show NFKB1 ELISA Kits) and IRAK1 (show IRAK1 ELISA Kits)/AP-1 (show JUN ELISA Kits) signaling.
Dectin-1 (show CLEC7A ELISA Kits) and Dectin-2 (show CLEC6A ELISA Kits) seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production
TNF (show TNF ELISA Kits) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF ELISA Kits)-induced JNK (show MAPK8 ELISA Kits) activation and cell death.
The effects of OXSI-2 identified in this study provide context for the role of Syk in inflammasome signaling and demonstrate its importance in oxidative signaling upstream of inflammasome activation and downstream of ion flux.
Mincle (show CLEC4E ELISA Kits) Activation and the Syk/Card9 (show CARD9 ELISA Kits) Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye
Syk deletion in myeloid cells is protective in mouse nephrotoxic serum nephritis.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase