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TNF (show TNF ELISA Kits) activates Mule (show HUWE1 ELISA Kits) by inducing the dissociation of Mule (show HUWE1 ELISA Kits) from its inhibitor ARF. Inhibition of Mule (show HUWE1 ELISA Kits) phosphorylation by silencing Syk prevents this, thereby inhibiting Mule (show HUWE1 ELISA Kits) E3 ligase activity and TNF (show TNF ELISA Kits)-induced JNK (show MAPK8 ELISA Kits) activation and cell death.
Study establishes P-SYK as a critical biomarker in AML (show RUNX1 ELISA Kits) that identifies tumors sensitive to SYK inhibition, identifies an at-risk patient population, and allows for the monitoring of target inhibition during treatment.
LMPs are important pro-apoptotic regulators for Rb cells through reduction of SYK expression.
Data suggest that immune complexes (ICs (show DNAI1 ELISA Kits)) of FCGR3A (show CD16 ELISA Kits)-SYK play critical role in activation of CD4 (show CD4 ELISA Kits)+ T-cells and thus in modulation of adaptive immunity; such ICs (show DNAI1 ELISA Kits) are present in blood from patients with systemic lupus erythematosus.
Syk activation is prominent in infiltrating myeloid cells in human rapidly progressive glomerulonephritis
Results suggest that the activated Syk-mediated TRAF6 (show TRAF6 ELISA Kits) pathway leads to aberrant activation of B cells in SLE.
this study shows that the treatment of cells with inducers of stress granule formation leads to the recruitment of Syk to these protein-RNA complexes
The differential requirements of ZAP70 (show ZAP70 ELISA Kits) and SYK during thymic development.
these data support the translation of approaches targeting Syk with fostamatinib to the clinic for patients with relapsed and possibly even newly diagnosed Waldenstrom macroglobulinemia
Syk is constitutively associated with TLR4 (show TLR4 ELISA Kits).
Dectin-1 (show CLEC7A ELISA Kits) and Dectin-2 (show CLEC6A ELISA Kits) seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production
TNF (show TNF ELISA Kits) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF ELISA Kits)-induced JNK (show MAPK8 ELISA Kits) activation and cell death.
The effects of OXSI-2 identified in this study provide context for the role of Syk in inflammasome signaling and demonstrate its importance in oxidative signaling upstream of inflammasome activation and downstream of ion flux.
Mincle (show CLEC4E ELISA Kits) Activation and the Syk/Card9 (show CARD9 ELISA Kits) Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye
Syk deletion in myeloid cells is protective in mouse nephrotoxic serum nephritis.
Src (show SRC ELISA Kits)/Syk-dependent signalling stabilises platelet adhesion to podoplanin (show PDPN ELISA Kits)
These results provide new insights into the mechanisms by which SYK regulates MHC-II expression via autophagy in macrophages.
Syk mediates airway contractility in the normal and allergic airways, independent of its role and function in leukocytes, and supports a paracrine role for airway epithelial Syk in modulating airway smooth muscle activity.
Syk expression by DCs is necessary for IL-23p19 (show IL23A ELISA Kits) production in response to C. albicans
The Syk inhibitor fostamatinib prevented bleomycin-induced fibrosis and inflammation in the skin and in the lung. The anti-fibrotic effect of fostamatinib is linked to reduced Syk phosphorylation and TGF-beta (show TGFB1 ELISA Kits) expression.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase