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The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 (show ZAP70 ELISA Kits) Tandem Src (show SRC ELISA Kits) Homology 2 Domains, tSH2 (show tshz2 ELISA Kits). While Syk tSH2 (show tshz2 ELISA Kits) has a rather broad substrate scope, ZAP-70 (show ZAP70 ELISA Kits) tSH2 (show tshz2 ELISA Kits) required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
SYK mediates the actions of EPO (show EPO ELISA Kits) and GM-CSF (show CSF2 ELISA Kits) and coordinates with TGF-beta (show TGFB1 ELISA Kits) in erythropoiesis.
study demonstrates that high SYK expression is a common feature of CD21 (show CR2 ELISA Kits)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (show BTK ELISA Kits) and phospholipase Cgamma2
IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (show IL1B ELISA Kits) responses in a TLR2 (show TLR2 ELISA Kits)- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (show NLRP3 ELISA Kits) inflammasome-dependent IL-1beta (show IL1B ELISA Kits) production in macrophages.
High SYK expression is associated with lymphangioleiomyomatosis.
NKp65 utilizes a hemi-immunoreceptor tyrosine-based activation motif -like motif for cellular activation that requires Syk, although Syk appears not to be recruited to NKp65.
Syk is a key regulator of Hoxa9 (show HOXA9 ELISA Kits)/Meis1 (show MEIS1 ELISA Kits)-driven acute myeloid leukemia (show BCL11A ELISA Kits).
Data show that spleen tyrosine kinase (SYK) and proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (AKT1 (show AKT1 ELISA Kits)) proteins were increased in the cytoplasm of the cells forming Mallory-Denk bodies.
B cell receptor signaling component, SYK, caused PAX5 (show PAX5 ELISA Kits) tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (show PRDM1 ELISA Kits) promoter by PAX5 (show PAX5 ELISA Kits) was attenuated by this phosphorylation.
Pharmacological inhibitors of SYK activity significantly reduced the engulfment of oxLDL microbeads in the presence of serum factors, but had little effect on IgG phagocytosis.
identified both Syk and Src (show SRC ELISA Kits) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
ephrin B3 (show EFNB3 ELISA Kits)/EphB2 (show EPHB2 ELISA Kits) are obvious candidates for driving the Syk-dependent repulsive response.
The effect of Smad4 (show SMAD4 ELISA Kits) was at least partially mediated by the downstream effectors Syk and ROCK2 (show ROCK2 ELISA Kits) transcription in megakaryocytes.
Gene expression analysis of lung tissues revealed that HDM (show HDAC3 ELISA Kits)-induced expression of IL-17 (show IL17A ELISA Kits) and CXCL-1 (show CXCL1 ELISA Kits) was significantly attenuated in both Sykdel/del and GSK143-treated mice. CONCLUSION: Syk inhibitors may play a role in the management of neutrophilic asthma
collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI (show GP6 ELISA Kits).
Pharmacological Syk inhibition might provide a safe therapeutic strategy to prevent arterial thrombosis and to limit infarct progression in acute stroke.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase