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These results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec (show NR4A3 ELISA Kits) family and suggest that Nef provides a mechanistic link between HIV-1 and Itk (show ITK ELISA Kits) signaling in the viral life cycle.
results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC (show NR4A3 ELISA Kits) chimeric protein and that fusion of the TFG (NTD) to the TEC (show NR4A3 ELISA Kits) protein produces a gain-of-function chimeric product
Overexpression of Tec (show NR4A3 ELISA Kits) is associated with the tumorigenesis and development of liver cancer.
Tec (show NR4A3 ELISA Kits) kinase has a crucial role in regulating FGF2 (show FGF2 ELISA Kits) secretion under various physiological conditions
inhibits CD25 (show IL2RA ELISA Kits) expression in human T-lymphocytes
Chemotactic factor-induced recruitment and activation of Tec (show NR4A3 ELISA Kits) family kinases in human neutrophils
The AF2 domain of the orphan nuclear receptor (show ESRRB ELISA Kits) is essential for the transcriptional activity of the oncogenic fusion protein EWS (show EWSR1 ELISA Kits)
specificity in tyrosine phosphorylation of SH3 domains in vitro is high and, therefore, SH3 domain (show ITSN1 ELISA Kits) phosphorylation is required for a distinct function in signaling
Tec (show NR4A3 ELISA Kits) overexpression in lymphocyte cell lines is sufficient to induce phospholipase Cgamma (PLC (show HSPG2 ELISA Kits)-gamma) phosphorylation and NFAT (show NFATC1 ELISA Kits) (nuclear factor of activated T cells) activation.
Btk/Tec kinases control sustained calcium signaling via site-specific phosphorylation of key residues within the phospholipase C gamma2 SH2-SH3 linker
Tec (show NR4A3 ELISA Kits) enhances c-Maf (show MAF ELISA Kits)-dependent IL-4 (show IL4 ELISA Kits) promoter activity. This effect of Tec (show NR4A3 ELISA Kits) is counteracted by Ptpn22 (show PTPN22 ELISA Kits), which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF ELISA Kits) thereby attenuating its transcriptional activity.
identify dectin-1 (show CLEC7A ELISA Kits) as the pathogen recognition receptor being required for Syk (show SYK ELISA Kits)-dependent Tec (show NR4A3 ELISA Kits) activation.
Btk (show BTK ELISA Kits), Tec (show NR4A3 ELISA Kits), Bmx (show BMX ELISA Kits) are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Tec (show NR4A3 ELISA Kits) kinase can act as a prosurvival factor and is regulated by IGF-I (show IGF1 ELISA Kits) in human neutrophils through PI(3 (show PI3 ELISA Kits))K activation.
TEC (show NR4A3 ELISA Kits) promotes hepatocyte proliferation and regeneration and is involved in Hepatocyte Growth Factor (show HGF ELISA Kits)-induced Erk (show EPHB2 ELISA Kits) signaling pathway.
our data indicated a critical role for Tec (show NR4A3 ELISA Kits) in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44 (show CD44 ELISA Kits)(high)CD62L (show SELL ELISA Kits)(-) effector/memory Th17 populations.
These experiments expand the role of the Tec (show NR4A3 ELISA Kits) family in the heart, identifying the Tec (show NR4A3 ELISA Kits) isoform as an ischemic injury-induced isoform
the absence of the Tec (show NR4A3 ELISA Kits) family kinase Itk (show ITK ELISA Kits), which regulates the production of Th2 cytokines, leads to resistance in the C57BL/6 background, but decreases susceptibility on the BALB/c background
Our results demonstrate a crucial role for Tec (show NR4A3 ELISA Kits)
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
, tyrosine-protein kinase Tec
, Tec protein tyrosine kinase
, transient erythroblastopenia of childhood
, tec protein tyrosine kinase
, Tyrosine-protein kinase Tec
, tyrosine-protein kinase Tec-like
, cytoplasmic tyrosine kinase, Dscr28C related