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anti-Mouse (Murine) AGRP Antibodies:
anti-Human AGRP Antibodies:
anti-Rat (Rattus) AGRP Antibodies:
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It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y (show NPY Antibodies) and are functionally involved in the systemic response to fasting.
These findings indicate that the relevance of AgRP to POMC (show POMC Antibodies) neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
CRFR1 (show CRHR1 Antibodies), in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY (show NPY Antibodies) neurons in mice.
Data show that agouti-related protein (AgRP)-glucocorticoid receptor (show NR3C1 Antibodies) knockout (GR-/-) mice are resistant to diet-induced obesity.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp) and neuropeptide Y (Npy (show NPY Antibodies)) gene expression similarly in Ghrelin (show GHRL Antibodies)+/+, Ghrelin (show GHRL Antibodies)-/-, ghrelin receptor Ghsr (show GHSR Antibodies)+/+, and Ghsr (show GHSR Antibodies)-/- mice.
Suppression of sympathetic tone in AgRP-Sirt1 (show SIRT1 Antibodies)/(--) mice reversed osteopenia in transgenic animals.
Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 (show DMBX1 Antibodies) (deleted in malignant brain tumors 1 (show DMBT1 Antibodies)) and AgRP is important in appetite regulation.
mTORC1 in Agrp neurons controls circadian expression of orexigenic neuropeptides but is dispensable for the regulation of feeding behavior and energy metabolism
Absence of Mc3rs (but not Ghsrs) was associated with lower AgRP/Npy (show NPY Antibodies) expression, suggesting attenuated responses to signals of negative energy balance.
data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (show MC4R Antibodies)), pro-opiomelanocortin (POMC (show POMC Antibodies)), apolipoprotein E (APOE (show APOE Antibodies)) and agouti-related protein (AGRP) with obesity in the North Indian population.
CSF (show CSF2 Antibodies) AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.
human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor (show MC4R Antibodies)
Variations in genes AGRP, CPE (show CPE Antibodies), GHRL (show GHRL Antibodies), GLP1R (show GLP1R Antibodies), HTR2A, NPY1R (show NPY1R Antibodies), NPY5R (show NPY5R Antibodies), SOCS3 (show SOCS3 Antibodies) and STAT3 (show STAT3 Antibodies) showed modest associations with BMI in European Americans.
Elevations in AgRP also favor the diagnosis of ectopic ACTH (show POMC Antibodies) syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker.
AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients.
Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.
Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin (show LEP Antibodies) concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance.
AgRP and NPY (show NPY Antibodies) are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH (show POMC Antibodies) immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms.
(Nle4, d-Phe7)-alphaMSH (show POMC Antibodies) (NDP (show NDP Antibodies)-alphaMSH (show POMC Antibodies)) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor (show MC4R Antibodies)
Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP (show NDP Antibodies)-alphaMSH (show POMC Antibodies)-induced cortisol production through its antagonistic properties towards MSH (show POMC Antibodies) at the level of MC4-R (show MC4R Antibodies)
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
, orexigenic neuropeptide
, agouti related protein homolog (mouse)
, agouti related protein