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genetic analyses of indel loci in ACE (show ACE Proteins), DJ-1 (show PARK7 Proteins), and GIGYF2 genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
Full-length GIGYF2 coimmunoprecipitates with AGO2 (show EIF2C2 Proteins) in human cells, and upon tethering to a reporter mRNA, GIGYF2 exhibits strong, dose-dependent silencing activity, involving both mRNA destabilization and translational repression.
required, this finding may shed light on the GIGYF2-associated mechanisms that lead to PD and suggests insulin (show INS Proteins) dysregulation as a disease-specific mechanism for both PD and cognitive dysfunction.
Results suggest that the N56S and N457T of GIGYF2 are risk factors for Parkinson's disease in Caucasians, but not in Asians
GIGYF2 and the zinc finger protein 598 (ZNF598) are identifie (show EIF4E Proteins)d as components of the 4EHP complex.
Our result indicated that SCNA, LRRK2 (show LRRK2 Proteins), UCHL1 (show UCHL1 Proteins), HtrA2 (show HTRA2 Proteins) and GIGYF2 genes' mutations might not be a main reason for Chinese Autosomal dorminant Parkinson's disease
within the Chinese population, the c.297T>C p.Ala99Ala polymorphism of the GIGYF2 gene may be associated with an increased risk of developing Parkinson disease.
These data, together with those recently reported by other groups, suggest that GIGYF2 is unlikely to be the PARK11 gene.
No clearly pathogenic mutations are identified in GIGYF2 and ATP13A2 (show ATP13A2 Proteins) in Brazilian patients with early-onset Parkinson's disease.
The results of this study did not support a role for GIGYF2 in the genetic etiology of Belgian Parkinson disease.
Negative regulation of Grb10 (show GRB10 Proteins) Interacting GIGYF2 protein on IGF-1 (show IGF1 Proteins) receptor signaling pathway caused diabetic mice cognitive impairment.
Disruption of the eukaryotic translation initiation factor 4E (show EIF4E Proteins) - Gigyf2 complex leads to increased translation and perinatal lethality in mice.
Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF1 (show IGF1 Proteins) signaling.
identification of proteins linked to insulin (show INS Proteins)-like growth factor (IGF-I (show IGF1 Proteins)) receptors by the Grb10 (show GRB10 Proteins) adapter and modulate IGF-I (show IGF1 Proteins) signaling
The protein encoded by this gene interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene.
trinucleotide repeat containing 15
, GRB10 interacting GYF protein 2
, PERQ amino acid-rich with GYF domain-containing protein 2
, PERQ amino acid rich, with GYF domain 3
, Parkinson disease (autosomal recessive, early onset) 11
, trinucleotide repeat-containing gene 15 protein
, GRB10-interacting GYF protein 2