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anti-Human STRA6 Antibodies:
anti-Mouse (Murine) STRA6 Antibodies:
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Human Polyclonal STRA6 Primary Antibody for WB - ABIN528577
Muenzner, Tuvia, Deutschmann, Witte, Tolkachov, Valai, Henze, Sander, Raila, Schupp: Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor ? activity. in Molecular and cellular biology 2013
Show all 3 Pubmed References
Mouse (Murine) Polyclonal STRA6 Primary Antibody for ELISA, WB - ABIN4356642
Kawaguchi, Yu, Honda, Hu, Whitelegge, Ping, Wiita, Bok, Sun: A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. in Science (New York, N.Y.) 2007
Human Polyclonal STRA6 Primary Antibody for WB - ABIN4892475
Isken, Golczak, Oberhauser, Hunzelmann, Driever, Imanishi, Palczewski, von Lintig: RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. in Cell metabolism 2008
this study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of type 2 diabetes mellitus(T2DM) while RARRES2 (show RARRES2 Antibodies) polymorphism could not predict the risk of T2DM
A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly.
These data establish that holo-RBP (show RBP4 Antibodies) and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers.
Evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, in STRA6.
STRA6 has a role for regulating retinoid homeostasis and in helping to program signaling that drives proliferation and differentiation of human skin cells
Stra6, a retinoic acid-responsive (show GPRC5A Antibodies) gene, participates in p53 (show TP53 Antibodies)-induced apoptosis after DNA damage.
Analysis of FRAS1 (show FRAS1 Antibodies) and STRA6 mutations in the same family with eye anomalies.
Findings suggest that heterozygosity for the STRA6 gene mutation may be associated with ocular abnormalities.
TTR (show TTR Antibodies) blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling.
STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin.
The STRA6 is potent regulators of diurnal insulin (show INS Antibodies) responses and suggest that the holo-RBP (show RBP4 Antibodies)/STRA6 signaling axis may represent a novel therapeutic target in type II diabetes.
Suppression of STRA6 cascades is involved in renal apoptosis and fibrosis caused by electronegative low density lipoproteins.
These results showed that STRA6 is critical for vitamin A homeostasis and the adaption of this process to the fluctuating supply of the vitamin.-
Studies indicate that STRA6 is indeed a bona fide vitamin A transporter and provide novel insights into the regulatory mechanism that governs vitamin A homeostasis in peripheral tissues.
Total vitamin A levels are dramatically lower in the eyes of STRA6 KO mice as compared to those of WT mice, but the levels in other organs were not significantly affected after STRA6 deletion under vitamin A sufficient conditions.
STRA6 reduction in adipocytes in adipose-Stra6(-/-) mice.
Rbp4 (show RBP4 Antibodies) and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and RARalpha (show RARA Antibodies) activity.
STRA6 in tissues other than the eye appears to be the coupling of circulating holo-RBP (show RBP4 Antibodies) levels to cell signaling, in turn regulating key processes such as insulin (show INS Antibodies) response.
Stra6, a retinoic acid-responsive gene, participates in p53 (show TP53 Antibodies)-induced apoptosis after DNA damage.
STRA6 was identified in retinal pigment epithelium cells as a specific membrane receptor for retinol binding protein (RBP (show RBP4 Antibodies)); STRA6 binds to RBP (show RBP4 Antibodies) with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP (show RBP4 Antibodies) complex
study identifies an essential functional domain in STRA6
this study presents the structure of zebrafish STRA6 determined to 3.9-angstrom resolution by single-particle cryo-electron microscopy.
STRA6 deficiency leads to accumulation of RBP-4 (show RBP4 Antibodies) bound vitamin A and developmental abnormalities.
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene.
stimulated by retinoic acid 6 homolog
, stimulated by retinoic acid gene 6 homolog
, stimulated by retinoic acid gene 6 protein homolog
, retinoic acid-responsive protein
, stimulated by retinoic acid gene 6 protein
, stimulated by retinoic acid gene 6 homolog (mouse)