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Browse our UCHL1 Proteins (UCHL1)

Full name:
Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) Proteins (UCHL1)
On www.antibodies-online.com are 41 Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) Proteins from 17 different suppliers available. Additionally we are shipping UCHL1 Antibodies (557) and UCHL1 Kits (23) and many more products for this protein. A total of 637 UCHL1 products are currently listed.
Synonyms:
AW822034, C88048, cb358, gad, MGC132191, PARK5, PGP9.5, PGP 9.5, PGP95, R75593, Uch-L1, UCHL-1, uchl1, wu:fc55h08
list all proteins Gene Name GeneID UniProt
UCHL1 22223 Q9R0P9
UCHL1 7345 P09936
UCHL1 29545 Q00981

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UCHL1 Proteins (UCHL1) by Origin

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Top referenced UCHL1 Proteins

  1. Human UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2181887 : Liu, Fallon, Lashuel, Liu, Lansbury: The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. in Cell 2002 (PubMed)
    Show all 3 references for ABIN2181887

  2. Rat (Rattus) UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2009143 : Wada, Kito, Caskey, Yeh, Kamitani: Cleavage of the C-terminus of NEDD8 by UCH-L3. in Biochemical and biophysical research communications 1998 (PubMed)
    Show all 3 references for ABIN2009143

  3. Mouse (Murine) UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN2008165 : Choi, Levey, Weintraub, Rees, Gearing, Chin, Li: Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN2008165

  4. Human UCHL1 Protein expressed in Escherichia coli (E. coli) - ABIN667048 : Sakurai, Ayukawa, Setsuie, Nishikawa, Hara, Ohashi, Nishimoto, Abe, Kudo, Sekiguchi, Sato, Aoki, Noda, Wada: Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation. in Journal of cell science 2005 (PubMed)
    Show all 2 references for ABIN667048

More Proteins for UCHL1 Interaction Partners

Mouse (Murine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs.

  2. The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Proteins)-induced transformation of, germinal center B cells.

  3. Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (show SMN1 Proteins). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (show SMN1 Proteins).

  4. Parkin (show PARK2 Proteins) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (show UBE2N Proteins)/Uev1a E2 ubiquitin-conjugating enzyme (show UBE2L6 Proteins) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.

  5. defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM

  6. UCH-L1 facilitates PDGF (show PDGFA Proteins)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts

  7. UCHL1 upregulation in ACTN4 (show ACTN4 Proteins)-associated FSGS (show ACTN4 Proteins).

  8. downregulated miR (show MLXIP Proteins)-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 (show HSPA5 Proteins) and UCHL1 protein levels

  9. The proteases HtrA2/Omi (show HTRA2 Proteins) and UCH-L1 regulate TNF (show TNF Proteins)-induced necroptosis.

  10. Activation of the NF-kappaB (show NFKB1 Proteins) signaling pathway could be the major pathogenic mechanism to up-regulate UCH-L1 in podocyte injury.

Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. This study demonstrated that UCH-L1 was detectible within 1 hour of injury and rose rapidly and peaked at 8 hours after injury and declined rapidly over 48 hours.

  2. This study establishes the importance of UCHL1 in neurodegeneration, provides new mechanistic insight about ubiquitin processing, and underlines the complexity of the different roles of UCHL1

  3. TGF-beta1 (show TGFB1 Proteins) can promote PGP9.5 expression in Cancer associated fibroblasts to facilitate the growth of cancer cells.

  4. PGP9.5 is also expressed in benign fibroblastic lesions

  5. cytoplasmic accumulation of P53 (show TP53 Proteins) was strongly associated with the unmethylated UCHL1 profile (P = 0.006), supporting the relationship between these two proteins in sporadic colorectal cancer

  6. UCHL1 has a role in Alzheimer Disease [review]

  7. UCHL1 expression is highly upregulated upon hepatic stellate cell (HSC (show FUT1 Proteins)) activation and is involved in the regulation of HSC (show FUT1 Proteins) proliferation

  8. UCH-L1 is a promising prognostic biomarker for GCAs and might play an important role in the carcinogenesis of gastric cancer.

  9. Folloing aneurysmal subarachnoid hemorrhage, eleevated UCH-L1 levels during the five-day follow-up were associated with unfavorable neurological outcome.

  10. UCH-L1 plays a crucial role in modulating the degradation of EGFR (show EGFR Proteins) and promoting malignant properties in multi-drug resistant breast cancer

Cow (Bovine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.

Pig (Porcine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.

  2. Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.

Horse (Equine) Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) interaction partners

  1. There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.

UCHL1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.

Alternative names and synonyms associated with UCHL1

  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1)
  • Ubiquitin carboxyl-terminal hydrolase isozyme L1 (uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100304750)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100348287)
  • ubiquitin carboxyl-terminal esterase L1 (LOC100357806)
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1)
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (Uchl1)
  • AW822034 protein
  • C88048 protein
  • cb358 protein
  • gad protein
  • MGC132191 protein
  • PARK5 protein
  • PGP9.5 protein
  • PGP 9.5 protein
  • PGP95 protein
  • R75593 protein
  • Uch-L1 protein
  • UCHL-1 protein
  • uchl1 protein
  • wu:fc55h08 protein

Protein level used designations for UCHL1

ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) , ubiquitin carboxyl-terminal esterase L1 , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin thioesterase L1 , ubiquitin C-terminal hydrolase , PGP 9.5 , PGP9.5 , UCH-L1 , ubiquitin carboxy-terminal hydrolase L1 , ubiquitin C-terminal hydrolase-L1 , ubiquitin carboxyl-terminal hydrolase L1 , ubiquitin thiolesterase L1

GENE ID SPECIES
325119 Danio rerio
461185 Pan troglodytes
479098 Canis lupus familiaris
751589 Taeniopygia guttata
770302 Gallus gallus
496780 Xenopus (Silurana) tropicalis
735204 Xenopus laevis
100196868 Salmo salar
100304750 Ictalurus punctatus
100348287 Oryctolagus cuniculus
100357806 Oryctolagus cuniculus
22223 Mus musculus
7345 Homo sapiens
29545 Rattus norvegicus
514394 Bos taurus
100714582 Cavia porcellus
396637 Sus scrofa
100033838 Equus caballus
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