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The UCHL1 may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation.
our study provides novel insights into the mechanisms of UCH-L1-mediated neurobiological functions and suggests that ubiquitination is an important regulatory signal for TrkB (show NTRK2 Proteins)
Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs.
The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene (show RAB1A Proteins)-induced transformation of, germinal center B cells.
Pharmacological inhibition of UCHL1 exacerbates rather than ameliorates disease symptoms in a mouse model of SMA (show SMN1 Proteins). Thus, pharmacological inhibition of UCHL1 is not a viable therapeutic target for SMA (show SMN1 Proteins).
Parkin (show PARK2 Proteins) mediates K63-linked polyubiquitination of UCH-L1 in cooperation with the Ubc13 (show UBE2N Proteins)/Uev1a E2 ubiquitin-conjugating enzyme (show UBE2L6 Proteins) complex and promotes UCH-L1 degradation by the autophagy-lysosome pathway.
defective UCHL1 function may be an early contributor to vulnerability of pancreatic beta-cells for protein misfolding and proteotoxicity, hallmark defects in islets of T2DM
UCH-L1 facilitates PDGF (show PDGFA Proteins)-BB-induced suppression of autophagic degradation of p21WAF1/Cip1 proteins in cardiac fibroblasts
UCHL1 upregulation in ACTN4 (show ACTN4 Proteins)-associated FSGS (show ACTN4 Proteins).
downregulated miR (show MLXIP Proteins)-181b induces neuroprotection against ischemic injury through negatively regulating HSPA5 (show HSPA5 Proteins) and UCHL1 protein levels
Familial mutations and post-translational modifications of UCH-L1 in Parkinson's disease have been summarized. (Review)
Aberrant expression of UCHL1 in pediatric high-grade gliomas may promote cell invasion, transformation, and self-renewal properties, at least in part, by modulating Wnt (show WNT2 Proteins)/Beta catenin (show CTNNB1 Proteins) activity
Suppression of MITF (show MITF Proteins) activity by UCHL1 via protein degradation might aid in the development of new therapeutic approaches for melanoma or dyspigmentation disorders.
Overexpression of UCH-L1 in MCF7 cells up-regulated MDR1, CD147 (show BSG Proteins), MMP2 (show MMP2 Proteins), and MMP9 (show MMP9 Proteins), which conferred multidrug resistance and promoted migration/invasion.
This study demonstrated that UCH-L1 was detectible within 1 hour of injury and rose rapidly and peaked at 8 hours after injury and declined rapidly over 48 hours.
This study establishes the importance of UCHL1 in neurodegeneration, provides new mechanistic insight about ubiquitin processing, and underlines the complexity of the different roles of UCHL1
TGF-beta1 (show TGFB1 Proteins) can promote PGP9.5 expression in Cancer associated fibroblasts to facilitate the growth of cancer cells.
PGP9.5 is also expressed in benign fibroblastic lesions
cytoplasmic accumulation of P53 (show TP53 Proteins) was strongly associated with the unmethylated UCHL1 profile (P = 0.006), supporting the relationship between these two proteins in sporadic colorectal cancer
UCHL1 has a role in Alzheimer Disease [review]
These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of These data indicate that antipolyspermy defense in bovine oocytes may rely on UCHL1-controlled functioning of cortical granules.
The elevation in UCH-L1 concentration is consistent with the severity of neural apoptosis following DHCA.
Data report that ubiquitin carboxy-terminal hydrolase 1 is expressed in spermatogonia located at the basement membrane of seminiferous tubules at high and low levels, but not in differentiated germ cells distant from the BM.
There was no difference in enteric neuronal density and distribution in the groups of animals with intestinal disease compared with those without, apart from two (out of 28) horses with intestinal disease that showed reduction in PGP 9.5 immunoreactivity.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.
ubiquitin carboxyl-terminal hydrolase isozyme L1
, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
, ubiquitin carboxyl-terminal esterase L1
, gracile axonal dystrophy
, neuron cytoplasmic protein 9.5
, protein gene product 9.5
, ubiquitin thioesterase L1
, ubiquitin C-terminal hydrolase
, PGP 9.5
, ubiquitin carboxy-terminal hydrolase L1
, ubiquitin C-terminal hydrolase-L1
, ubiquitin carboxyl-terminal hydrolase L1
, ubiquitin thiolesterase L1